PMID- 29760940
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2055-0294 (Print)
IS  - 2055-0294 (Electronic)
IS  - 2055-0294 (Linking)
VI  - 4
DP  - 2018
TI  - Analyses of non-benzodiazepine-induced adverse events and prognosis in elderly 
      patients based on the Japanese adverse drug event report database.
PG  - 10
LID - 10.1186/s40780-018-0106-2 [doi]
LID - 10
AB  - BACKGROUND: The contents of the guidelines for the use of non-benzodiazepines 
      (Z-drugs) differ slightly between THE JAPANESE SOCIETY OF SLEEP RESEARCH and THE 
      JAPAN GERIATRIC SOCIETY, and the recommended directions are conflicting. 
      Therefore, we analyzed the use of the Japanese Adverse Drug Event Report database 
      (JADER) for identifying adverse events (AEs) caused by Z-drugs and clarifying 
      their occurrence trend and prognosis. METHODS: The signal value for comparison 
      was calculated by using the proportional reporting ratio (PRR) and chi-squared 
      test (chi(2)) results of data of elderly and non-elderly patients. Among AEs for 
      which signals were detected in the elderly, we determined that those with lower 
      signal values for non-elderly patients that were half the signal value of the 
      elderly should be used with particular caution in the elderly. We also compared 
      the prognoses. RESULTS: The AEs with > 1 risk ratio (RR) in elderly and 
      non-elderly patients were regarded as those that should be noted in the prognosis 
      of AEs in elderly patients. Furthermore, 28 AEs were detected in elderly 
      patients' signals. In this study, in addition to movement disorders such as 
      "falls" and "bone fractures," identified by two academic societies, signal 
      characteristics of the elderly were obtained for psychiatric disorders and eye 
      disorders. CONCLUSIONS: There was no difference in prognosis, but these disorders 
      could reduce the quality of life of patients. Therefore, we consider that in 
      prescribing appropriate drug therapy for insomnia, attention should be paid to 
      the occurrence of the AEs caused by the Z-drugs revealed by this study and the 
      guidelines.
FAU - Noguchi, Yoshihiro
AU  - Noguchi Y
AUID- ORCID: 0000-0002-9110-9604
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Ueno, Anri
AU  - Ueno A
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Katsuno, Hayato
AU  - Katsuno H
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Otsubo, Manami
AU  - Otsubo M
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Yoshida, Aki
AU  - Yoshida A
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Kanematsu, Yuta
AU  - Kanematsu Y
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Sugita, Ikuto
AU  - Sugita I
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Tachi, Tomoya
AU  - Tachi T
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
FAU - Tsuchiya, Teruo
AU  - Tsuchiya T
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
AD  - Community Health Support and Research Center, 5-6-1, kikuchichou, Gifu, 501-6242 
      Japan.
FAU - Teramachi, Hitomi
AU  - Teramachi H
AD  - 1Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, 1-25-4, 
      Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
AD  - 3Laboratory of Community Healthcare Pharmacy, Gifu Pharmaceutical University, 
      1-25-4, Daigakunishi, Gifu, 501-1196 Japan. ISNI: 0000 0000 9242 8418. GRID: 
      grid.411697.c
LA  - eng
PT  - Journal Article
DEP - 20180507
PL  - England
TA  - J Pharm Health Care Sci
JT  - Journal of pharmaceutical health care and sciences
JID - 101672177
PMC - PMC5937044
OTO - NOTNLM
OT  - Elderly patients
OT  - Japanese adverse drug event report database (JADER)
OT  - Non-benzodiazepine (Z-drug)
OT  - Signal detection
COIS- Not applicable.Although Laboratory of Community Healthcare Pharmacy, Gifu 
      Pharmaceutical University, is financially supported by donations from WELCIA 
      YAKKYOKU CO., LTD., the authors report no conflicts of interest regarding the 
      content of this article.Springer Nature remains neutral with regard to 
      jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/05/16 06:00
MHDA- 2018/05/16 06:01
PMCR- 2018/05/07
CRDT- 2018/05/16 06:00
PHST- 2018/01/14 00:00 [received]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/16 06:00 [entrez]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2018/05/16 06:01 [medline]
PHST- 2018/05/07 00:00 [pmc-release]
AID - 106 [pii]
AID - 10.1186/s40780-018-0106-2 [doi]
PST - epublish
SO  - J Pharm Health Care Sci. 2018 May 7;4:10. doi: 10.1186/s40780-018-0106-2. 
      eCollection 2018.