PMID- 29761881
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20220927
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 24
IP  - 7
DP  - 2018 Oct
TI  - Expression of stem cell markers Nanog and Nestin in lip squamous cell carcinoma 
      and actinic cheilitis.
PG  - 1209-1216
LID - 10.1111/odi.12891 [doi]
AB  - Cancer stem cell (CSC) proteins have been observed in several lesions and are 
      associated with tumor beginning, evolution, and resistance to treatment. 
      OBJECTIVES: To investigate the presence of NANOG, NESTIN, and beta-tubulin in lip 
      squamous cell carcinoma (LSCC), actinic cheilitis (AC), and normal epithelium 
      (NE). MATERIALS AND METHODS: Thirty cases of LSCC, thirty cases of AC (both 
      analyzed according to the WHO classification and AC according to the binary 
      classification), and twenty cases of NE were submitted to an immunohistochemical 
      study. RESULTS: NANOG was more expressed in the nuclei of AC compared to NE 
      (p = 0.007), as well as in high-risk AC cases (p = 0.017) and well-differentiated 
      LSCCs (no significance). There was an accumulation of nuclear NANOG from mild to 
      moderate and severe ACs. NESTIN was significantly less present in NE compared to 
      AC (p = 0.001) and LSCC (p = 0.003). There was a higher expression in severe 
      dysplasia or high-risk AC and well-differentiated LSCC. These results indicate an 
      upregulation of NANOG and NESTIN in the early stages of carcinogenesis. beta-tubulin 
      was intensely present in all lesions. CONCLUSION: The results suggest an 
      upregulation of NANOG and NESTIN in the biological behavior these diseases, 
      mainly in the transformation from AC to LSCC.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights 
      reserved.
FAU - Scotti, Fernanda M
AU  - Scotti FM
AD  - Dentistry Graduate Program, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
FAU - Mitt, Veronica C
AU  - Mitt VC
AD  - Multidisciplinary Residence Program, Federal University of Santa Catarina, 
      Florianopolis, Brazil.
FAU - Vieira, Daniella Sc
AU  - Vieira DS
AD  - Pathology Department, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
FAU - Biz, Michelle T
AU  - Biz MT
AD  - Morphology Sciences Department, Federal University of Santa Catarina, 
      Florianopolis, Brazil.
FAU - Castro, Renata G
AU  - Castro RG
AD  - Dentistry Department, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
FAU - Modolo, Filipe
AU  - Modolo F
AUID- ORCID: 0000-0002-5395-0486
AD  - Dentistry Graduate Program, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
AD  - Pathology Department, Federal University of Santa Catarina, Florianopolis, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180628
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - 0 (NANOG protein, human)
RN  - 0 (NES protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nestin)
RN  - 0 (Tubulin)
RN  - Actinic cheilitis
CIN - Oral Dis. 2022 Oct;28(7):2057-2058. PMID: 34837299
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cheilitis/*metabolism/pathology
MH  - Epithelium/metabolism
MH  - Humans
MH  - Lip Neoplasms/*metabolism/pathology
MH  - Nanog Homeobox Protein/*metabolism
MH  - Neoplastic Stem Cells/*metabolism
MH  - Nestin/*metabolism
MH  - Tubulin/metabolism
MH  - Up-Regulation
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - Nestin
OT  - cancer stem cell
OT  - lip cancer
OT  - oral cancer
EDAT- 2018/05/16 06:00
MHDA- 2019/01/04 06:00
CRDT- 2018/05/16 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2018/05/16 06:00 [entrez]
AID - 10.1111/odi.12891 [doi]
PST - ppublish
SO  - Oral Dis. 2018 Oct;24(7):1209-1216. doi: 10.1111/odi.12891. Epub 2018 Jun 28.