PMID- 29761969
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 34
IP  - 5
DP  - 2017 Oct 1
TI  - [A numerical simulation of dendritic cells migration and induction of T cell 
      specific proliferation during the initiation of skin inflammatory].
PG  - 797-802
LID - 10.7507/1001-5515.201702050 [doi]
AB  - Dendritic cells (DCs) are the most potent and specialized antigen-presenting 
      cells (APCs) currently known, which play a crucial role in initiating and 
      amplifying both the innate and adaptive immune responses. During the process of 
      immune function, migration ability of DCs and the number of effector T cells 
      which activated by DCs are closely related to the efficiency of immune function. 
      However, because of the complexity of immune system, in the immune response 
      process caused by the skin chronic inflammatory, much is still unknown about the 
      dynamic changes of cell count with time. Therefore, we created a differential 
      equations model to reflect the initial stages of the immune response process 
      caused by the skin chronic inflammatory via setting the function and initial 
      conditions of parameters. The results showed that the model was able to simulate 
      migration and proliferation of cells in vivo within realistic time scales in 
      accordance with the proliferation and migration efficiency in real terms. In 
      addition, the preliminary model can biologically predict the realistic dynamics 
      of DCs and T cells at different time points. All these results may provide a 
      theoretical reference for studying the immune function of DCs as well as guiding 
      the clinical treatment for immune related diseases further.
FAU - Hu, Wenhui
AU  - Hu W
AD  - School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, 
      P.R.China.
FAU - Huang, Wenzhu
AU  - Huang W
AD  - School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, 
      P.R.China;Key laboratory of Biology and Engineering, Guizhou Medical University, 
      Guiyang 550025, P.R.China.
FAU - Hu, Zuquan
AU  - Hu Z
AD  - School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, 
      P.R.China;Key laboratory of Biology and Engineering, Guizhou Medical University, 
      Guiyang 550025, P.R.China.
FAU - Zeng, Zhu
AU  - Zeng Z
AD  - School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, 
      P.R.China;Key laboratory of Biology and Engineering, Guizhou Medical University, 
      Guiyang 550025, P.R.China.zengzhu100@sina.com.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
PMC - PMC9935461
OTO - NOTNLM
OT  - dendritic cells
OT  - mathematical model
OT  - ordinary differential equations
OT  - skin inflammation
EDAT- 2018/05/16 06:00
MHDA- 2018/05/16 06:01
PMCR- 2017/10/01
CRDT- 2018/05/16 06:00
PHST- 2018/05/16 06:00 [entrez]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2018/05/16 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - swyxgcxzz-34-5-797 [pii]
AID - 10.7507/1001-5515.201702050 [doi]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Oct 1;34(5):797-802. doi: 
      10.7507/1001-5515.201702050.