PMID- 29761987
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230702
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 34
IP  - 6
DP  - 2017 Dec 1
TI  - [Comparison of planning quality and delivery efficiency between volumetric 
      modulated arc therapy and dynamic intensity modulated radiation therapy for 
      nasopharyngeal carcinoma with more than 4 prescribed dose levels].
PG  - 907-913
LID - 10.7507/1001-5515.201607004 [doi]
AB  - The aim of this study is to compare the planning quality and delivery efficiency 
      between dynamic intensity modulated radiation therapy (d-IMRT) and dual arc 
      volumetric modulated arc therapy (VMAT) systematically for nasopharyngeal 
      carcinoma (NPC) patients with multi-prescribed dose levels, and to analyze the 
      correlations between target volumes and plan qualities. A total of 20 patients of 
      NPC with 4-5 prescribed dose levels to achieve simultaneous integrated boost 
      (SIB) treated by sliding window d-IMRT in our department from 2014 to 2015 were 
      re-planned with dual arc VMAT. All optimization objectives for each VMAT plan 
      were as the same as the corresponding d-IMRT plan. The dose parameters for 
      targets and organ at risk (OAR), the delivery time and monitor units (MU) in two 
      sets of plans were compared respectively. The treatment accuracy was tested by 
      three dimensional dose validation system. Finally, the correlations between the 
      difference of planning quality and the volume of targets were discussed. The 
      conform indexes (CIs) of planning target volumes (PTVs) in VMAT plans were 
      obviously high than those in d-IMRT plans ( P < 0.05), but no significant 
      correlations between the difference of CIs and the volume of targets were 
      discovered ( P > 0.05). The target coverage and heterogeneity indexes (HIs) of 
      PTV (1) and PGTV (nd) and PTV (3) in two sets of plans were consistent. The doses 
      of PTV (2) decreased and HIs were worse in VMAT plans. VMAT could provide better 
      spinal cord and brainstem sparing, but increase mean dose of parotids. The 
      average number of MUs and delivery time for d-IMRT were 3.32 and 2.19 times of 
      that for VMAT. The gamma-index (3 mm, 3%) analysis for each plans was more than 97% 
      in COMPASS ((R)) measurement for quality assurance (QA). The results show that 
      target dose coverages in d-IMRT and VMAT plans are similar for NPC with 
      multi-prescribed dose levels. VMAT could improve the the CIs of targets, but 
      reduce the dose to the target volume in neck except for PGTV (nd). The biggest 
      advantages of VMAT over d-IMRT are delivery efficiency and QA.
FAU - Jia, Pengfei
AU  - Jia P
AD  - Department of Radiation Oncology, Affiliated Hospital of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China.
FAU - Xu, Jun
AU  - Xu J
AD  - Department of Radiation Oncology, Affiliated Hospital of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China.
FAU - Zhou, Xiaoxi
AU  - Zhou X
AD  - Department of Radiation Oncology, Affiliated Hospital of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China.
FAU - Chen, Jian
AU  - Chen J
AD  - Department of Radiation Oncology, Affiliated Hospital of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China.
FAU - Tang, Lemin
AU  - Tang L
AD  - Department of Radiation Oncology, Affiliated Hospital of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China;Medical School of Nongtong University, 
      Nantong, Jiangsu 226001, P.R.China.nttlm@126.com.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = 
      Shengwu yixue gongchengxue zazhi
JID - 9426398
PMC - PMC9935327
OTO - NOTNLM
OT  - multi-prescribed dose levels
OT  - nasopharyngeal carcinoma
OT  - quality assurance
OT  - volumetric modulated arc therapy
EDAT- 2018/05/16 06:00
MHDA- 2018/05/16 06:01
PMCR- 2017/12/01
CRDT- 2018/05/16 06:00
PHST- 2018/05/16 06:00 [entrez]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2018/05/16 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - swyxgcxzz-34-6-907 [pii]
AID - 10.7507/1001-5515.201607004 [doi]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2017 Dec 1;34(6):907-913. doi: 
      10.7507/1001-5515.201607004.