PMID- 29763158
OWN - NLM
STAT- MEDLINE
DCOM- 20180531
LR  - 20180803
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 33
IP  - 2
DP  - 2017 Feb
TI  - [Chemotherapy increases FcgammaRⅡB content in peripheral blood of the patients with 
      lung squamous cell carcinoma].
PG  - 220-4
AB  - OBJECTIVE: To detect the FcgammaRⅡB content of monocytes and B cells,the 
      concentration of soluble FcgammaRⅡB( s FcgammaRⅡB) and its antibodies in the peripheral 
      blood of patients with lung squamous cell carcinoma( LSCC) before and after 
      chemotherapy. METHODS: The expression and localization of FcgammaR Ⅱ B on monocytes 
      and B cells were detected by immunofluorescence technique; the expression of FcgammaR 
      Ⅱ B mRNA was examined by quantitative real-time PCR; Western blotting was 
      performed to detect the expression of FcgammaRⅡB protein; the serum concentrations of 
      s FcgammaRⅡB,s FcgammaRⅡB-Ig G complex,anti-FcgammaRⅡB autoantibody were determined by ELISA. 
      RESULTS: The expression of FcgammaRⅡB on monocytes and B cells,the total s FcgammaRⅡB and 
      anti-FcgammaRⅡB antibody content in the sera of LSCC patients were lower than those 
      in healthy volunteers. Chemotherapy enhanced the expression of FcgammaRⅡB both on the 
      detected cell surface and in the peripheral blood of patients with LSCC,and 
      increased the serum concentration of anti-FcgammaR Ⅱ B autoantibodies as well. In 
      addition,the concentration of s FcgammaR Ⅱ B-Ig G in the peripheral blood was higher 
      in LSCC patients than that in healthy volunteers,and it decreased after 
      chemotherapy. CONCLUSION: The level of FcgammaRⅡB decreases in LSCC patients,but it 
      rises after chemotherapy.
FAU - Lu, Jingjing
AU  - Lu J
FAU - Cao, Xiuqin
AU  - Cao X
FAU - Yang, Zhiwei
AU  - Yang Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (FCGR2B protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - B-Lymphocytes/metabolism
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/*blood/drug therapy
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*blood/drug therapy
MH  - Male
MH  - Monocytes/metabolism
MH  - Neoplasm Proteins/*blood
MH  - RNA, Messenger/blood
MH  - Receptors, IgG/*blood
EDAT- 2017/02/01 00:00
MHDA- 2018/06/01 06:00
CRDT- 2018/05/16 06:00
PHST- 2018/05/16 06:00 [entrez]
PHST- 2017/02/01 00:00 [pubmed]
PHST- 2018/06/01 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Feb;33(2):220-4.