PMID- 29763586
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20190408
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 273
DP  - 2019 Mar 1
TI  - Postnatal testis development in the collared peccary (Tayassu tajacu), with 
      emphasis on spermatogonial stem cells markers and niche.
PG  - 98-107
LID - S0016-6480(18)30157-6 [pii]
LID - 10.1016/j.ygcen.2018.05.013 [doi]
AB  - Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, 
      where Leydig cells (LC) are mainly located in cords around the seminiferous 
      tubules (ST) lobes. This peculiar arrangement is very useful to better 
      investigate and understand the role of LC in spermatogonial stem cells (SSCs) 
      biology and niche. Recent studies from our laboratory using adult peccaries have 
      shown that the undifferentiated type A spermatogonia (A(und) or SSCs) are 
      preferentially located in ST regions adjacent to the intertubular compartment 
      without LC. Following these studies, our aims were to investigate the collared 
      peccary postnatal testis development, from birth to adulthood, with emphasis on 
      the establishment of LC cytoarchitecture and the SSCs niche. Our findings 
      demonstrated that the unique LC cytoarchitecture is already present in the 
      neonate peccary's testis, indicating that this arrangement is established during 
      fetal development. Based on the most advanced germ cell type present at each time 
      period evaluated, puberty (the first sperm release in the ST lumen) in this 
      species was reached at around one year of age, being preceded by high levels of 
      estradiol and testosterone and the end of Sertoli cell proliferation. Almost all 
      gonocytes and SSCs expressed Nanos1, Nanos2 and GFRA1. The analysis of SSCs 
      preferential location indicated that the establishment of SSCs niche is 
      coincident with the occurrence of puberty. Taken together, our findings 
      reinforced and extended the importance of the collared peccary as an animal model 
      to investigate testis function in mammals, particularly the aspects related to 
      testis organogenesis and the SSCs biology and niche.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lara, Nathalia de Lima E Martins
AU  - Lara NLEM
AD  - Laboratory of Cellular Biology, Department of Morphology, Federal University of 
      Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Costa, Guilherme Mattos Jardim
AU  - Costa GMJ
AD  - Laboratory of Cellular Biology, Department of Morphology, Federal University of 
      Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Avelar, Gleide Fernandes
AU  - Avelar GF
AD  - Laboratory of Cellular Biology, Department of Morphology, Federal University of 
      Minas Gerais, Belo Horizonte, MG, Brazil.
FAU - Guimaraes, Diva Anelie
AU  - Guimaraes DA
AD  - Laboratory of Animal Reproduction, Biological Sciences Institute, Federal 
      University of Para, Belem, PA, Brazil.
FAU - Franca, Luiz Renato
AU  - Franca LR
AD  - Laboratory of Cellular Biology, Department of Morphology, Federal University of 
      Minas Gerais, Belo Horizonte, MG, Brazil; National Institute for Amazonian 
      Research, Manaus, AM, Brazil. Electronic address: lrfranca@inpa.gov.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180512
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Biomarkers)
RN  - 0 (Hormones)
SB  - IM
MH  - Animals
MH  - Artiodactyla/*growth & development
MH  - Biomarkers/*metabolism
MH  - Body Weight
MH  - Hormones/metabolism
MH  - Male
MH  - Organ Size
MH  - Phenotype
MH  - Seminiferous Tubules/metabolism
MH  - Sertoli Cells/metabolism
MH  - Spermatogenesis
MH  - Spermatogonia/*cytology/metabolism
MH  - *Stem Cell Niche
MH  - Stem Cells/*metabolism
MH  - Testis/anatomy & histology/*growth & development/metabolism
OTO - NOTNLM
OT  - Collared peccary
OT  - Leydig cell
OT  - Puberty
OT  - Sertoli cell
OT  - Spermatogonial stem cell niche
OT  - Testis development
EDAT- 2018/05/16 06:00
MHDA- 2019/04/09 06:00
CRDT- 2018/05/16 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/05/06 00:00 [revised]
PHST- 2018/05/11 00:00 [accepted]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/05/16 06:00 [entrez]
AID - S0016-6480(18)30157-6 [pii]
AID - 10.1016/j.ygcen.2018.05.013 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2019 Mar 1;273:98-107. doi: 10.1016/j.ygcen.2018.05.013. 
      Epub 2018 May 12.