PMID- 29763886
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 47
IP  - 1
DP  - 2018
TI  - Perfusion Computer Tomography Assessment of the Effect of Angiotensin II On Blood 
      Flow Distribution in Rabbits with Intrarenal VX2 Tumors.
PG  - 97-106
LID - 10.1159/000489752 [doi]
AB  - BACKGROUND/AIMS: Unlike other organs, which only have one set of capillary 
      network, the renal microvasculature consists of two sets of capillary network 
      series connected by efferent arterioles. Angiotensin II constricts the efferent 
      glomerular artery. Hence, renal tumor blood flow (BF) distribution may be 
      different from tumors in other organs. This study aims to investigate the effects 
      of angiotensin II on the hemodynamics of intrarenal VX2 tumors using perfusion 
      computed tomography(CT). METHODS: Twenty-four male New Zealand white rabbits were 
      randomly divided into three groups: groups A (blank controls), group B (negative 
      controls), and group C (angiotensin II-treated animals). Group B and C were 
      established to the model of intrarenal VX2 tumors. Furthermore, perfusion CT of 
      the kidney was performed in each group. Prior to perfusion CT scan in group C, 
      the mean arterial blood was elevated to 150-160 mmHg by angiotensin II. The BF, 
      blood volume (BV), mean transit time (MTT), capillary permeability-surface area 
      product (PS), and relative permeability-surface area product (RPS) of tumors and 
      renal tissues were calculated. RESULTS: Compared with normal renal cortex tissues 
      in group A, the BF, BV and PS values of tumors in group B were significantly 
      lower, MTT was prolonged and RPS increased. Compared with group B, only the RPS 
      of these tumors increased from 83.23 +/- 29.17% to 120.94 +/- 31.84% by angiotensin 
      II infusion. Angiotensin II significantly increased the RPS value of the renal 
      cortex distant from the tumor (CDT) and the right renal cortex (RRC). 
      CONCLUSIONS: Perfusion CT can accurately observe the influence of angiotensin II 
      on normal and tumor BF in kidneys. This clarifies the effect of angiotensin II on 
      intrarenal tumor hemodynamics.
CI  - (c) 2018 The Author(s). Published by S. Karger AG, Basel.
FAU - Xu, Ying-Jin
AU  - Xu YJ
AD  - Department of Radiology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Wu, Song-Hong
AU  - Wu SH
AD  - Nuclear Medicine, Affiliated Hospital of Hebei University, Baoding, China.
FAU - Liu, Huai-Jun
AU  - Liu HJ
AD  - Department of Radiology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Niu, Pei
AU  - Niu P
AD  - College of Medicine, Hebei University, Baoding, China.
FAU - Shen, Wen-Zeng
AU  - Shen WZ
AD  - College of Medicine, Hebei University, Baoding, China.
FAU - Xu, Ying-Jie
AU  - Xu YJ
AD  - Department of Radiology, Wangdu County Hospital, Wangdu, China.
FAU - Yin, Xiao-Ping
AU  - Yin XP
AD  - Department of Radiology, Affiliated Hospital of Hebei University, Baoding, China.
FAU - Zhang, Tian-Le
AU  - Zhang TL
AD  - Department of Radiology, Affiliated Hospital of Hebei University, Baoding, China.
FAU - Li, Xue-Zhao
AU  - Li XZ
AD  - College of Medicine, Hebei University, Baoding, China.
FAU - Guo, Fei
AU  - Guo F
AD  - College of Medicine, Hebei University, Baoding, China.
FAU - Niu, Xiao-Long
AU  - Niu XL
AD  - College of Medicine, Hebei University, Baoding, China.
FAU - Zhu, Jin-Song
AU  - Zhu JS
AD  - College of Medicine, Hebei University, Baoding, China.
LA  - eng
PT  - Journal Article
DEP - 20180509
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (Vasoconstrictor Agents)
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Hemodynamics/*drug effects
MH  - Kidney/*blood supply/diagnostic imaging/drug effects
MH  - Kidney Neoplasms/*blood supply/diagnostic imaging/drug therapy
MH  - Male
MH  - Neovascularization, Pathologic/diagnostic imaging/drug therapy
MH  - Perfusion/methods
MH  - Rabbits
MH  - Tomography, X-Ray Computed/*methods
MH  - Vasoconstrictor Agents/*pharmacology
OTO - NOTNLM
OT  - Angiotensin II
OT  - Computed tomography perfusion imaging
OT  - Hemodynamics
OT  - Kidney
OT  - Rabbit
OT  - VX2 tumor
EDAT- 2018/05/16 06:00
MHDA- 2018/08/22 06:00
CRDT- 2018/05/16 06:00
PHST- 2017/09/04 00:00 [received]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/05/16 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
PHST- 2018/05/16 06:00 [entrez]
AID - 000489752 [pii]
AID - 10.1159/000489752 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2018;47(1):97-106. doi: 10.1159/000489752. Epub 2018 May 9.