PMID- 29765456
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 14
IP  - 3
DP  - 2018 Apr
TI  - Indomethacin-induced gastric damage in rats and the protective effect of donkey 
      milk.
PG  - 671-678
LID - 10.5114/aoms.2016.59645 [doi]
AB  - INTRODUCTION: Indomethacin is an anti-inflammatory drug with clearly known side 
      effects on gastric mucosa. New treatment and side effect prevention methods are 
      being studied. Donkey milk, as a nutritional support, has recently come into the 
      spotlight with its anti-oxidant features, high antibody content and low 
      allergenic properties. In this study, we investigated donkey milk's possible 
      protective effect against acute gastric mucosal damage by indomethacin. MATERIAL 
      AND METHODS: Four groups, each composed of 8 rats, were created. Rats in the 
      first and third groups were fed with standard rat chow, while those in the second 
      and fourth groups were additionally fed with 25 mg/kg of donkey milk per day via 
      nasogastric gavage. On the 11(th) day gastric mucosal damage was induced by oral 
      administration of 30 mg/kg of indomethacin to the rats in groups 3 and 4. Six h 
      later all rats were sacrificed and their stomachs were removed for macroscopic 
      and microscopic evaluation as well as biochemical examination of glutathione 
      (GSH) and malondialdehyde (MDA) levels. Tumor necrosis factor-alpha (TNF-alpha) 
      expression in the gastric mucosa was evaluated immunohistochemically. RESULTS: In 
      the donkey milk-indomethacin group, total area of erosion and degree of linear 
      ulceration were significantly lower than in the standard food-indomethacin group 
      (p < 0.05). Also, GSH levels were increased and MDA levels were decreased 
      significantly in this group. Tumor necrosis factor-alpha expression was more 
      prevalent and stronger in the gastritis group, while lower expression was 
      observed in the donkey milk group. CONCLUSIONS: Donkey milk was observed to have 
      significant protective effects against gastric damage induced by indomethacin.
FAU - Tastekin, Ebru
AU  - Tastekin E
AD  - Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey.
FAU - Ayvaz, Suleyman
AU  - Ayvaz S
AD  - Department of Pediatric Surgery, Faculty of Medicine, Trakya University, Edirne, 
      Turkey.
FAU - Usta, Ufuk
AU  - Usta U
AD  - Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey.
FAU - Aydogdu, Nurettin
AU  - Aydogdu N
AD  - Department of Physiology, Faculty of Medicine, Trakya University, Edirne, Turkey.
FAU - Cancilar, Ekrem
AU  - Cancilar E
AD  - Department of Pediatric Surgery, Faculty of Medicine, Trakya University, Edirne, 
      Turkey.
FAU - Puyan, Fulya Oz
AU  - Puyan FO
AD  - Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20160520
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC5949905
OTO - NOTNLM
OT  - donkey milk
OT  - gastric damage
OT  - indomethacin
OT  - protective effect
EDAT- 2018/05/17 06:00
MHDA- 2018/05/17 06:01
PMCR- 2018/04/01
CRDT- 2018/05/17 06:00
PHST- 2015/07/10 00:00 [received]
PHST- 2016/01/20 00:00 [accepted]
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/17 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 27470 [pii]
AID - 10.5114/aoms.2016.59645 [doi]
PST - ppublish
SO  - Arch Med Sci. 2018 Apr;14(3):671-678. doi: 10.5114/aoms.2016.59645. Epub 2016 May 
      20.