PMID- 29765838 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2213-6312 (Electronic) IS - 2213-6304 (Print) IS - 2213-6304 (Linking) VI - 1 IP - 1 DP - 2015 Oct 9 TI - Downstream Consequences of Exercise Through the Action of BDNF. PG - 143-148 LID - 10.3233/BPL-150017 [doi] AB - Physical exercise produces many beneficial responses in the brain, which affect cognitive function, blood flow, neurogenesis and resistance to injury. However, the exact mechanisms whereby exercise produces an induction in the brain are not well understood. A significant consequence is the induction of growth factors, such as Brain-derived Neurotrophic Factor (BDNF). Cognitive decline that occurs with aging, as well as progression of neurodegenerative diseases, are strongly correlated with decreases in BDNF. In this article, we discuss the properties of neurotrophins and the mechanisms that can account for the ability of exercise to promote brain plasticity through BDNF. FAU - Sleiman, Sama F AU - Sleiman SF AD - Department of Natural Sciences, Lebanese American University, Byblos, Lebanon. FAU - Chao, Moses V AU - Chao MV AD - Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, Physiology & Neuroscience and Psychiatry, New York University Langone Medical Center, New York, NY, USA. LA - eng GR - R56 NS021072/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20151009 PL - Netherlands TA - Brain Plast JT - Brain plasticity (Amsterdam, Netherlands) JID - 101669568 PMC - PMC5939187 OTO - NOTNLM OT - BDNF OT - Exercise OT - memory OT - psychiatric diseases EDAT- 2015/10/09 00:00 MHDA- 2015/10/09 00:01 PMCR- 2015/10/09 CRDT- 2018/05/17 06:00 PHST- 2018/05/17 06:00 [entrez] PHST- 2015/10/09 00:00 [pubmed] PHST- 2015/10/09 00:01 [medline] PHST- 2015/10/09 00:00 [pmc-release] AID - BPL150017 [pii] AID - 10.3233/BPL-150017 [doi] PST - epublish SO - Brain Plast. 2015 Oct 9;1(1):143-148. doi: 10.3233/BPL-150017.