PMID- 29766581
OWN - NLM
STAT- MEDLINE
DCOM- 20190307
LR  - 20200930
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 30
IP  - 26
DP  - 2018 Jun
TI  - Corannulene-Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay 
      for Boosted Cancer Phototheranostics In Vivo.
PG  - e1801065
LID - 10.1002/adma.201801065 [doi]
AB  - Fluorescent nanoparticles (NPs) based on luminogens with aggregation-induced 
      emission characteristic (AIEgens), namely AIE dots, have received wide attention 
      because of their antiquenching attitude in emission and reactive oxygen species 
      (ROS) generation when aggregated. However, few reports are available on how to 
      control and optimize their fluorescence and ROS generation ability. Herein, it is 
      reported that enhancing the intraparticle confined microenvironment is an 
      effective approach to advanced AIE dots, permitting boosted cancer 
      phototheranostics in vivo. Formulation of a "rotor-rich" and inherently charged 
      near-infrared (NIR) AIEgen with 
      1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene 
      glycol)-2000] and corannulene-decorated PEG affords DSPE-AIE dots and Cor-AIE 
      dots, respectively. Compared to DSPE-AIE dots, Cor-AIE dots show 4.0-fold 
      amplified fluorescence quantum yield and 5.4-fold enhanced ROS production, 
      because corannulene provides intraparticle rigidity and strong interactions with 
      the AIEgen to restrict the intramolecular rotation of AIEgen to strongly suppress 
      the nonradiative decay and significantly facilitate the fluorescence pathway and 
      intersystem crossing. Thus, it tremendously promotes phototheranostic efficacies 
      in terms of NIR image-guided cancer surgery and photodynamic therapy using a 
      peritoneal carcinomatosis-bearing mouse model. Collectively, it not only provides 
      a novel strategy to advanced AIE dots for cancer phototheranostics, but also 
      brings new insights into the design of superior fluorescent NPs for biomedical 
      applications.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Gu, Xinggui
AU  - Gu X
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
AD  - Beijing Advanced Innovation Center for Soft Matter Science and Engineering, 
      Beijing University of Chemical Technology, Beijing, 100029, China.
FAU - Zhang, Xiaoyan
AU  - Zhang X
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, and College of Life Sciences, Nankai 
      University, Tianjin, 300071, China.
FAU - Ma, Huili
AU  - Ma H
AD  - Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials 
      (IAM), Nanjing Tech University (Nan-jingTech), 30 South Puzhu Road, Nanjing, 
      211800, China.
FAU - Jia, Shaorui
AU  - Jia S
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, and College of Life Sciences, Nankai 
      University, Tianjin, 300071, China.
FAU - Zhang, Pengfei
AU  - Zhang P
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
FAU - Zhao, Yanjun
AU  - Zhao Y
AD  - School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern 
      Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical 
      Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - Department of Urology, Tianjin First Central Hospital, Tianjin, 300192, P. R. 
      China.
FAU - Wang, Jianguo
AU  - Wang J
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
FAU - Zheng, Xiaoyan
AU  - Zheng X
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
FAU - Lam, Jacky W Y
AU  - Lam JWY
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
FAU - Ding, Dan
AU  - Ding D
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive 
      Materials, Ministry of Education, and College of Life Sciences, Nankai 
      University, Tianjin, 300071, China.
FAU - Tang, Ben Zhong
AU  - Tang BZ
AUID- ORCID: 0000-0002-0293-964X
AD  - Department of Chemistry, Hong Kong Branch of Chinese National Engineering 
      Research Center for Tissue Restoration and Reconstruction, Division of Life 
      Science, State Key Laboratory of Molecular Neuroscience, Institute for Advanced 
      Study, and Division of Biomedical Engineering, The Hong Kong University of 
      Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
AD  - NSFC Center for Luminescence from Molecular Aggregates, SCUT-HKUST Joint Research 
      Institute, State Key Laboratory of Luminescent Materials and Devices, South China 
      University of Technology, Guangzhou, 510640, China.
LA  - eng
PT  - Journal Article
DEP - 20180516
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (corannulene)
SB  - IM
MH  - Animals
MH  - Fluorescence
MH  - Mice
MH  - Nanoparticles
MH  - Neoplasms
MH  - Polycyclic Aromatic Hydrocarbons/*chemistry
OTO - NOTNLM
OT  - AIE nanodots
OT  - aggregation-induced emission
OT  - cancer phototheranostics
OT  - near-infrared fluorescence image-guided surgery
OT  - photodynamic therapy
EDAT- 2018/05/17 06:00
MHDA- 2019/03/08 06:00
CRDT- 2018/05/17 06:00
PHST- 2018/02/13 00:00 [received]
PHST- 2018/03/19 00:00 [revised]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2019/03/08 06:00 [medline]
PHST- 2018/05/17 06:00 [entrez]
AID - 10.1002/adma.201801065 [doi]
PST - ppublish
SO  - Adv Mater. 2018 Jun;30(26):e1801065. doi: 10.1002/adma.201801065. Epub 2018 May 
      16.