PMID- 29767374
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 2240-2993 (Electronic)
IS  - 0300-9009 (Linking)
VI  - 119
IP  - 3
DP  - 2019 Sep
TI  - The effect of CA1 dopaminergic system on amnesia induced by harmane in mice.
PG  - 369-377
LID - 10.1007/s13760-018-0926-8 [doi]
AB  - In the present study, the effects of bilateral injections of dopaminergic drugs 
      into the hippocampal CA1 regions (intra-CA1) on harmane-induced amnesia were 
      examined in mice. We used a single-trial step-down inhibitory avoidance task for 
      the assessment of memory acquisition in adult male mice. Our data indicated that 
      pre-training intra-peritoneal (i.p.) administration of harmane (12 mg/kg) 
      impaired memory acquisition. Moreover, intra-CA1 administration of dopamine D1 
      receptor agonist, SKF38393 (0.25 microg/mouse), dopamine D1 receptor antagonist, 
      SCH23390 (0.25 microg/mouse), dopamine D2 receptor agonist, quinpirole (0.125 and 
      0.25 microg/mouse) and dopamine D2 receptor antagonist, sulpiride (0.2 and 
      0.4 microg/mouse) decreased the learning of a single-trial inhibitory avoidance task. 
      Furthermore, pre-training intra-CA1 injection of sub-threshold doses of SKF38393 
      (0.0625 microg/mouse) or sulpiride (0.1 microg/mouse) increased pre-training harmane (4 
      and 8 mg/kg, i.p.)-induced amnesia. On the other hand, pre-training intra-CA1 
      injection of a sub-threshold dose of SCH23390 (0.0625 microg/mouse) reversed amnesia 
      induced by an effective dose of harmane (12 mg/kg; i.p.). In addition, 
      Pre-training intra-CA1 injection of quinpirole (0.0625 microg/mouse) had no effect on 
      memory impairment induced by harmane. These findings indicate the involvement of 
      CA1 dopaminergic system on harmane-induced impairment of memory acquisition.
FAU - Nasehi, Mohammad
AU  - Nasehi M
AD  - Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences 
      Branch, Islamic Azad University, Tehran, Iran.
FAU - Hasanvand, Sedigheh
AU  - Hasanvand S
AD  - Department of Biology, Faculty of Basic Sciences, Northern branch, Islamic Azad 
      University, Tehran, Iran.
FAU - Khakpai, Fatemeh
AU  - Khakpai F
AD  - Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences 
      Branch, Islamic Azad University, Tehran, Iran.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, 13145-784, Iran. zarinmr@ams.ac.ir.
AD  - Iranian National Center for Addiction Studies, Tehran University of Medical 
      Sciences, Tehran, Iran. zarinmr@ams.ac.ir.
AD  - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 
      zarinmr@ams.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20180516
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
RN  - 0 (Dopamine Agonists)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Dopamine D2 Receptor Antagonists)
RN  - 0 (Neurotoxins)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 4FHH5G48T7 (Harmine)
RN  - 82D6J0535P (harman)
SB  - IM
EIN - Acta Neurol Belg. 2018 Jun 28;:. PMID: 29956086
MH  - Amnesia/*chemically induced/*drug therapy
MH  - Animals
MH  - Avoidance Learning/*drug effects
MH  - Behavior, Animal/drug effects
MH  - CA1 Region, Hippocampal/*drug effects
MH  - Dopamine Agonists/administration & dosage/*pharmacology
MH  - Dopamine Antagonists/administration & dosage/*pharmacology
MH  - Dopamine D2 Receptor Antagonists/pharmacology
MH  - Harmine/*analogs & derivatives/pharmacology
MH  - Male
MH  - Mice
MH  - Neurotoxins/*pharmacology
MH  - Receptors, Dopamine D1/agonists/antagonists & inhibitors
MH  - Receptors, Dopamine D2/agonists
OTO - NOTNLM
OT  - Dopaminergic system
OT  - Harmane
OT  - Inhibitory avoidance
OT  - Memory
OT  - Mice
EDAT- 2018/05/17 06:00
MHDA- 2020/02/13 06:00
CRDT- 2018/05/17 06:00
PHST- 2018/02/20 00:00 [received]
PHST- 2018/04/16 00:00 [accepted]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2018/05/17 06:00 [entrez]
AID - 10.1007/s13760-018-0926-8 [pii]
AID - 10.1007/s13760-018-0926-8 [doi]
PST - ppublish
SO  - Acta Neurol Belg. 2019 Sep;119(3):369-377. doi: 10.1007/s13760-018-0926-8. Epub 
      2018 May 16.