PMID- 29768320
OWN - NLM
STAT- MEDLINE
DCOM- 20190416
LR  - 20231112
IS  - 1535-2811 (Electronic)
IS  - 1535-282X (Print)
IS  - 1535-2811 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Jun
TI  - Monocyte Chemoattractant Protein-1 as a Predictor of Coronary Atherosclerosis in 
      Patients Receiving Coronary Angiography.
PG  - 105-110
LID - 10.1097/HPC.0000000000000140 [doi]
AB  - BACKGROUND: Animal studies suggest that monocyte chemoattractant protein-1 
      (MCP-1) is a promising biomarker for coronary artery atherosclerosis (CAA), but 
      human studies have been inconclusive. OBJECTIVE: To determine potential 
      relationships between plasma MCP-1 and CAA in patients with acute chest pain. 
      METHODS: A secondary analysis of 150 patients enrolled in emergency department 
      chest pain risk stratification clinical investigations was conducted. 
      Participants with stored blood and known coronary phenotypes (determined by 
      coronary angiography) were selected using stratified randomization such that 50 
      patients were included into 3 groups: (1) no angiographic evidence of CAA, (2) 
      nonobstructive CAA, and (3) obstructive CAA (stenosis >/= 70%). Plasma MCP-1 levels 
      were determined by enzyme-linked immunosorbent assay. The association between 
      MCP-1 and obstructive CAA or any CAA was modeled using logistic regression. 
      Variables in the unreduced model included age, sex, race, prior diagnosis of CAA 
      or acute coronary syndrome, hyperlipidemia, hypertension, diabetes, smoking, and 
      cardiac troponin I measurement. RESULTS: Among the 150 participants, 65.3% 
      (98/150) had invasive coronary angiography and 34.7% (52/150) had coronary 
      computed tomographic angiography. Myocardial infarction occurred in 27.3% 
      (41/150) and coronary revascularization occurred in 26% (39/150) of the 
      participants. Each 10 pg/mL increase in MCP-1 measurement was associated with an 
      odds ratio of 1.12 (95% confidence interval, 1.06-1.19) for obstructive CAA. 
      MCP-1 remained a significant predictor of obstructive CAA and any CAA after 
      adjustment for age, sex, race, traditional cardiac risk factors, and cardiac 
      troponin I. CONCLUSIONS: MCP-1 is independently associated with CAA among 
      emergency department patients with chest pain.
FAU - Mahler, Simon A
AU  - Mahler SA
AD  - From the Department of Emergency Medicine, Wake Forest School of Medicine, 
      Winston-Salem, NC.
FAU - Register, Thomas C
AU  - Register TC
AD  - Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC.
FAU - Riley, Robert F
AU  - Riley RF
AD  - Division of Cardiology, University of Washington, Seattle, WA.
FAU - D'Agostino, Ralph B Jr
AU  - D'Agostino RB Jr
AD  - Division of Public Health Sciences, Wake Forest School of Medicine, 
      Winston-Salem, NC.
FAU - Stopyra, Jason P
AU  - Stopyra JP
AD  - From the Department of Emergency Medicine, Wake Forest School of Medicine, 
      Winston-Salem, NC.
FAU - Miller, Chadwick D
AU  - Miller CD
AD  - From the Department of Emergency Medicine, Wake Forest School of Medicine, 
      Winston-Salem, NC.
LA  - eng
GR  - R21 HL097131/HL/NHLBI NIH HHS/United States
GR  - P30 AG049638/AG/NIA NIH HHS/United States
GR  - M01 RR007122/RR/NCRR NIH HHS/United States
GR  - L30 HL120008/HL/NHLBI NIH HHS/United States
GR  - R01 HL118263/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Crit Pathw Cardiol
JT  - Critical pathways in cardiology
JID - 101165286
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Catheterization
MH  - Chemokine CCL2/*blood
MH  - Computed Tomography Angiography
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction
MH  - Myocardial Revascularization
MH  - Odds Ratio
PMC - PMC5959046
MID - NIHMS910993
EDAT- 2018/05/17 06:00
MHDA- 2019/04/17 06:00
PMCR- 2019/06/01
CRDT- 2018/05/17 06:00
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2019/04/17 06:00 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 00132577-201806000-00009 [pii]
AID - 10.1097/HPC.0000000000000140 [doi]
PST - ppublish
SO  - Crit Pathw Cardiol. 2018 Jun;17(2):105-110. doi: 10.1097/HPC.0000000000000140.