PMID- 29768357
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20220419
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 20
DP  - 2018 May
TI  - Dysembryoplastic neuroepithelial tumor-like pilocytic astrocytoma: A case report.
PG  - e10755
LID - 10.1097/MD.0000000000010755 [doi]
LID - e10755
AB  - RATIONALE: Pilocytic astrocytoma (PA) typically shows biphasic pattern with a 
      mixture of loose microcystic and compact regions, in which it is not uncommon to 
      see heterogeneous morphology. However, there has not been reported in the 
      literatures of the PA type that shows similarity to dysembryoplastic 
      neuroepithelial tumor (DNT) in both histological morphology and immunophenotype. 
      PATIENT CONCERNS: The present study described a case of PA affecting the right 
      temporal-occipital lobe in a 22-year-old male patient. Morphologically, it 
      composed of totally distinctive microcystic pattern. The classical biphasic 
      pattern of PA was not observed. Immunohistochemically, neuronal marker NeuN was 
      expressed in tumor cells scattered in the background which simulated its 
      expression morphology in DNT. However, KIAA1549-BRAF fusion gene was identified 
      by fluorescence in situ hybridization (FISH), supporting for the diagnosis of PA. 
      DIAGNOSES: DNT-like PA (WHO grade I). INTERVENTIONS: The tumor was totally 
      removed via a right temporal-occipital craniotomy. OUTCOMES: The patient is free 
      of local recurrence and dissemination eleven months after surgical resection of 
      the lesion. LESSONS: We herein report a rare case of DNT-like PA. For diagnosis, 
      KIAA1549-BRAF fusion gene should be detected under similar situation.
FAU - Liao, Jia-Ming
AU  - Liao JM
AD  - Department of Clinical Laboratory, Southern District of Anhui Provincial Hospital 
      High Magnetic Field Laboratory, Chinese Academy of Sciences Department of 
      Pathology, Southern District of Anhui Provincial Hospital, Hefei, Anhui, China.
FAU - Wang, Wei
AU  - Wang W
FAU - Xie, Jing
AU  - Xie J
FAU - Wu, Hai-Bo
AU  - Wu HB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (BRAF-KIAA1549 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - *Astrocytoma/diagnosis/genetics/pathology/surgery
MH  - *Brain Neoplasms/diagnosis/genetics/pathology/surgery
MH  - Craniotomy/*methods
MH  - Diagnosis, Differential
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neoplasms, Neuroepithelial/*diagnosis
MH  - Occipital Lobe/diagnostic imaging/surgery
MH  - *Oncogene Proteins, Fusion/analysis/genetics
MH  - Temporal Lobe/diagnostic imaging/surgery
MH  - Teratoma/*diagnosis
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5976299
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/05/17 06:00
MHDA- 2018/05/23 06:00
PMCR- 2018/05/18
CRDT- 2018/05/17 06:00
PHST- 2018/05/17 06:00 [entrez]
PHST- 2018/05/17 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2018/05/18 00:00 [pmc-release]
AID - 00005792-201805180-00037 [pii]
AID - MD-D-18-01148 [pii]
AID - 10.1097/MD.0000000000010755 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 May;97(20):e10755. doi: 10.1097/MD.0000000000010755.