PMID- 29769455
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20200225
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 26
IP  - 1
DP  - 2019 Jan 1
TI  - Tenascin C: A Potential Biomarker for Predicting the Severity of Coronary 
      Atherosclerosis.
PG  - 31-38
LID - 10.5551/jat.42887 [doi]
AB  - AIMS: Coronary artery disease (CAD) is the leading cause of mortality and 
      morbidity worldwide and one of the greatest threats to public health. Tenascin C 
      (TNC) is an extracellular matrix glycoprotein that is found in low concentrations 
      in normal tissues and is enhanced by a range of cardiovascular pathologies. This 
      study aimed to evaluate the value of TNC in assessing the severity of 
      atherosclerosis measured by the Gensini score. METHODS: A total of 157 patients 
      with chest pains who underwent selective coronary angiography for suspected 
      coronary atherosclerosis were enrolled. The patients were divided into the CAD 
      group and non-CAD group according to symptoms and angiography. Demographic data 
      and laboratory analyses were collected. RESULTS: The mean TNC level was 
      significantly higher in the CAD group than in the non-CAD group (p＜0.001). A 
      significant positive correlation between TNC levels and Gensini score (p＜0.01, 
      r=0.672) was found. ROC curve analysis demonstrated that the cutoff value for TNC 
      at 89.48 ng/mL was well differentiated in the CAD and non-CAD groups. 
      Furthermore, TNC was also a good predictor for a higher Gensini score (the third 
      tertile) in the ROC curve analysis. When the cutoff was accepted as 100.91 ng/mL, 
      the sensitivity and specificity were 82.7% and 79%, respectively. CONCLUSION: A 
      significant relationship was found between the Gensini score and serum TNC level. 
      TNC levels can be considered in risk assessments for CAD before angiography.
FAU - Gao, Wen
AU  - Gao W
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
FAU - Li, Jian
AU  - Li J
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
FAU - Ni, Huanchun
AU  - Ni H
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
FAU - Shi, Haiming
AU  - Shi H
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
FAU - Qi, Zhiyong
AU  - Qi Z
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University.
FAU - Zhu, Shouguo
AU  - Zhu S
AD  - Department of Cardiology, Yunnan Kungang Hospital, Kunming.
FAU - Hao, Chuanming
AU  - Hao C
AD  - Department of Nephrology, Huashan Hospital, Fudan University.
FAU - Xie, Qionghong
AU  - Xie Q
AD  - Department of Nephrology, Huashan Hospital, Fudan University.
FAU - Luo, Xinping
AU  - Luo X
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
FAU - Xie, Kun
AU  - Xie K
AD  - Department of Cardiology, Huashan Hospital, Fudan University.
LA  - eng
PT  - Journal Article
DEP - 20180517
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Biomarkers)
RN  - 0 (TNC protein, human)
RN  - 0 (Tenascin)
SB  - IM
MH  - Aged
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Coronary Artery Disease/blood/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - ROC Curve
MH  - *Severity of Illness Index
MH  - Tenascin/*blood
PMC - PMC6308263
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Coronary artery disease
OT  - Gensini score
OT  - Tenascin C
COIS- The authors report no relationships that could be construed as a conflict of 
      interest.
EDAT- 2018/05/18 06:00
MHDA- 2019/06/14 06:00
PMCR- 2019/01/01
CRDT- 2018/05/18 06:00
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.5551/jat.42887 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2019 Jan 1;26(1):31-38. doi: 10.5551/jat.42887. Epub 2018 
      May 17.