PMID- 29769579
OWN - NLM
STAT- MEDLINE
DCOM- 20191023
LR  - 20191023
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 May 16
TI  - HLA-class II haplotypes and Autism Spectrum Disorders.
PG  - 7639
LID - 10.1038/s41598-018-25974-9 [doi]
LID - 7639
AB  - Infections and autoimmunity are associated with autism spectrum disorders (ASD), 
      with both strongly influenced by the genetic regulation of the human leukocyte 
      antigen (HLA) system. The relationship between ASD and the HLA genetic diversity 
      requires further investigation. Using a case control design, the distribution of 
      HLA class II-DRB1 and DQB1 alleles, genotypes and haplotypes were investigated in 
      ASD patients, versus healthy controls (HC). ASD patients meeting DSM-IV TR 
      criteria and HC (474 and 350 respectively) were genotyped at medium resolution 
      using a Luminex-based SSO technology. Comparisons of genotypes, allele 
      frequencies associated with a haplotype analysis were performed. Results 
      indicate: (i) the HLA-DRB1 *11-DQB1*07 haplotype was more prevalent in ASD 
      patients, versus HC (Pc = 0.001), partially replicating previous data and 
      possibly linking to gastro-intestinal (GI)-related pro-inflammatory processes, 
      given that this haplotype associates with pediatric celiac disorders; (ii) the 
      HLA-DRB1 *17-DQB1*02 haplotype was higher in HC, versus ASD patients 
      (Pc = 0.002), indicating that this is a protective haplotype. Using the Autism 
      Diagnostic Interview to assess clinical dimensions, higher scores on social 
      (Pc = 0.006) and non-verbal functioning (Pc = 0.004) associated with the DRB1 *11 
      DQB1*07 haplotype. Our results support HLA involvement in ASD, with possible 
      relevance to GI and gut-brain axis dysregulation.
FAU - Bennabi, Meriem
AU  - Bennabi M
AD  - INSERM, U1160, Hopital Saint Louis, Paris, France.
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France.
AD  - Fondation FondaMental, Creteil, France.
FAU - Gaman, Alexandru
AU  - Gaman A
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France.
AD  - Fondation FondaMental, Creteil, France.
FAU - Delorme, Richard
AU  - Delorme R
AD  - Fondation FondaMental, Creteil, France.
AD  - DHU Protect, AP-HP, Service de psychiatrie de l'enfant et de l'adolescent, 
      Hopital Robert Debre, Paris, France.
AD  - Departement de genetique humaine et fonctions cognitives, Institut Pasteur, 
      Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris-Cite, Paris, France.
FAU - Boukouaci, Wahid
AU  - Boukouaci W
AD  - INSERM, U1160, Hopital Saint Louis, Paris, France.
FAU - Manier, Celine
AU  - Manier C
AD  - INSERM, U1160, Hopital Saint Louis, Paris, France.
FAU - Scheid, Isabelle
AU  - Scheid I
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France.
AD  - Fondation FondaMental, Creteil, France.
FAU - Si Mohammed, Nassima
AU  - Si Mohammed N
AD  - Fondation FondaMental, Creteil, France.
FAU - Bengoufa, Djaouida
AU  - Bengoufa D
AD  - Laboratoire Jean Dausset and LabEx Transplantex, Hopital Saint Louis, Paris, 
      France.
FAU - Charron, Dominique
AU  - Charron D
AD  - INSERM, U1160, Hopital Saint Louis, Paris, France.
AD  - Universite Paris Diderot, Sorbonne Paris-Cite, Paris, France.
AD  - Laboratoire Jean Dausset and LabEx Transplantex, Hopital Saint Louis, Paris, 
      France.
FAU - Krishnamoorthy, Rajagopal
AU  - Krishnamoorthy R
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France.
AD  - Fondation FondaMental, Creteil, France.
FAU - Leboyer, Marion
AU  - Leboyer M
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France.
AD  - Fondation FondaMental, Creteil, France.
AD  - DHU PePSY, AP-HP, Pole de Psychiatrie, Hopitaux Universitaires Henri Mondor, 
      Creteil, France.
AD  - Universite Paris-Est-Creteil, Faculte de medecine, Creteil, France.
FAU - Tamouza, Ryad
AU  - Tamouza R
AD  - INSERM, U1160, Hopital Saint Louis, Paris, France. tamouza.ryad@gmail.com.
AD  - INSERM, U955, Psychiatrie Translationnelle, Creteil, France. 
      tamouza.ryad@gmail.com.
AD  - Fondation FondaMental, Creteil, France. tamouza.ryad@gmail.com.
AD  - Universite Paris Diderot, Sorbonne Paris-Cite, Paris, France. 
      tamouza.ryad@gmail.com.
AD  - Laboratoire Jean Dausset and LabEx Transplantex, Hopital Saint Louis, Paris, 
      France. tamouza.ryad@gmail.com.
AD  - DHU PePSY, AP-HP, Pole de Psychiatrie, Hopitaux Universitaires Henri Mondor, 
      Creteil, France. tamouza.ryad@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180516
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
CIN - Pediatr Neurol Briefs. 2018 Sep 14;32:9. PMID: 30258271
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Autism Spectrum Disorder/*genetics/*pathology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Prognosis
MH  - Young Adult
PMC - PMC5955937
COIS- The authors declare no competing interests.
EDAT- 2018/05/18 06:00
MHDA- 2019/10/24 06:00
PMCR- 2018/05/16
CRDT- 2018/05/18 06:00
PHST- 2018/02/19 00:00 [received]
PHST- 2018/04/26 00:00 [accepted]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2019/10/24 06:00 [medline]
PHST- 2018/05/16 00:00 [pmc-release]
AID - 10.1038/s41598-018-25974-9 [pii]
AID - 25974 [pii]
AID - 10.1038/s41598-018-25974-9 [doi]
PST - epublish
SO  - Sci Rep. 2018 May 16;8(1):7639. doi: 10.1038/s41598-018-25974-9.