PMID- 29769765
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 0972-124X (Print)
IS  - 0975-1580 (Electronic)
IS  - 0972-124X (Linking)
VI  - 22
IP  - 2
DP  - 2018 Mar-Apr
TI  - Comparison of serum tumor necrosis factor-alpha levels in rheumatoid arthritis 
      individuals with and without chronic periodontitis: A biochemical study.
PG  - 116-121
LID - 10.4103/jisp.jisp_362_17 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is indicated to play a major 
      function in chronic inflammatory disorders. OBJECTIVE: To assess and compare the 
      cytokine level (TNF-alpha) in the serum of chronic periodontitis (CP), rheumatoid 
      arthritis (RA), RA with CP, and healthy volunteers. MATERIALS AND METHODS: This 
      original research was carried out on 80 participants, divided into Group-I 20 RA 
      patients, Group-II 20 CP patients, Group III 20 RA with CP (RA + CP), and Group 
      IV 20 healthy volunteers. Clinical periodontal and rheumatological parameters 
      were assessed in all the four groups. Blood serum samples have been collected 
      from all individuals and investigated for levels of TNF-alpha by mean of 
      enzyme-linked immunosorbent assay. RESULTS: TNF-alpha level were remarkably elevated 
      in the RA+CP group (30.5+/-2.2) followed by RA group (17.9 +/- 3.6), and CP group 
      (11.9 +/- 0.96) when compared with the controls (5.5 +/- 3.3). The results showed a 
      statistical significance of P < 0.001. Correlation was not observed on 
      comparision of clinical periodontal parameters and Rheumatological parameters 
      with TNF-alpha levels. CONCLUSION: The outcome of this present research revealed the 
      presence of higher levels of TNF-alpha in individuals with RA with CP in our samples.
FAU - Thilagar, Sivasankari
AU  - Thilagar S
AD  - Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, 
      India.
FAU - Theyagarajan, Ramakrishnan
AU  - Theyagarajan R
AD  - Department of Periodontics, Adhi Parasakthi Dental College, Chennai, Tamil Nadu, 
      India.
FAU - Sudhakar, Uma
AU  - Sudhakar U
AD  - Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, 
      India.
FAU - Suresh, Snophia
AU  - Suresh S
AD  - Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, 
      India.
FAU - Saketharaman, Parthiban
AU  - Saketharaman P
AD  - Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, 
      India.
FAU - Ahamed, Nizar
AU  - Ahamed N
AD  - Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Indian Soc Periodontol
JT  - Journal of Indian Society of Periodontology
JID - 101499342
PMC - PMC5939018
OTO - NOTNLM
OT  - Inflammation
OT  - periodontitis
OT  - rheumatoid arthritis
OT  - serum
OT  - tumor necrosis factor-alpha
COIS- There are no conflicts of interest.
EDAT- 2018/05/18 06:00
MHDA- 2018/05/18 06:01
PMCR- 2018/03/01
CRDT- 2018/05/18 06:00
PHST- 2018/05/18 06:00 [entrez]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2018/05/18 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - JISP-22-116 [pii]
AID - 10.4103/jisp.jisp_362_17 [doi]
PST - ppublish
SO  - J Indian Soc Periodontol. 2018 Mar-Apr;22(2):116-121. doi: 
      10.4103/jisp.jisp_362_17.