PMID- 29770155
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against 
      Scopolamine-Induced Amnesia in C57BL/6 Mice.
PG  - 8941564
LID - 10.1155/2018/8941564 [doi]
LID - 8941564
AB  - We have investigated the neuroprotective and memory enhancing effect of 
      [6]-gingerol (GIN), a pungent ingredient of ginger, using an animal model of 
      amnesia. To determine the neuroprotective effect of GIN on cognitive dysfunction, 
      scopolamine (SCO, 1 mg/kg, i.p.) was injected into C57BL/6 mice, and a series of 
      behavioral tests were conducted. SCO-induced behavior changes and memory 
      impairments, such as decreased alteration (%) in Y-maze test, increased mean 
      escape latency in water maze test, diminished step-through latency in passive 
      avoidance test, and shortened freezing time in fear condition test, were 
      significantly prevented and restored by the oral administration of GIN (10 or 
      25 mg/kg/day). To further verify the neuroprotective mechanism of GIN, we have 
      focused on the brain-derived neurotrophic factor (BDNF). The administration of 
      GIN elevated the protein expression of BDNF, which was mediated via the 
      activation of protein kinase B/Akt- and cAMP-response element binding protein 
      (CREB) signaling pathway. These results suggest that GIN may have preventive 
      and/or therapeutic potentials in the management of memory deficit and cognitive 
      impairment in mice with amnesia.
FAU - Kim, Chang-Yul
AU  - Kim CY
AD  - Department of Pathology, College of Oriental Medicine, Daegu Haany University, 
      Daegu 42158, Republic of Korea.
FAU - Seo, Yongtaek
AU  - Seo Y
AD  - Department of Pharmacology, School of Medicine, Keimyung University, Daegu 42601, 
      Republic of Korea.
FAU - Lee, Chan
AU  - Lee C
AD  - Department of Pharmacology, School of Medicine, Keimyung University, Daegu 42601, 
      Republic of Korea.
FAU - Park, Gyu Hwan
AU  - Park GH
AUID- ORCID: 0000-0002-0718-5736
AD  - College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook 
      National University, Daegu 41566, Republic of Korea.
FAU - Jang, Jung-Hee
AU  - Jang JH
AUID- ORCID: 0000-0002-1563-364X
AD  - Department of Pharmacology, School of Medicine, Keimyung University, Daegu 42601, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180131
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5892971
EDAT- 2018/05/18 06:00
MHDA- 2018/05/18 06:01
PMCR- 2018/01/31
CRDT- 2018/05/18 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2018/01/04 00:00 [accepted]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2018/05/18 06:01 [medline]
PHST- 2018/01/31 00:00 [pmc-release]
AID - 10.1155/2018/8941564 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Jan 31;2018:8941564. doi: 
      10.1155/2018/8941564. eCollection 2018.