PMID- 29770471
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20220408
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 50
IP  - 7
DP  - 2018 Sep
TI  - Protective effects of the hydroalcoholic extract of Fumaria parviflora on 
      testicular injury induced by torsion/detorsion in adult rats.
PG  - e13047
LID - 10.1111/and.13047 [doi]
AB  - This study was designed to determine the effects of daily oral administration 
      (250 mg/kg) of the hydroalcoholic extract of Fumaria parviflora (FP) for 14 days 
      on the sperm parameters, oxidative stress parameters, serum testosterone levels, 
      expression of Bax and Bcl-2 genes, and apoptosis index of germ cells after 
      testicular torsion-detorsion (ischaemia-reperfusion, IR) injury model in rats. 
      Twenty-eight adult male Wistar rats were divided randomly into four groups of 
      seven each: sham operation, torsion-detorsion (TD), TD plus the hydroalcoholic 
      extract FP (TDFP) and only FP without TD application (FP). Testicular torsion was 
      created by rotating the left testis 720 degrees  in a counterclockwise direction; then, 
      after 4 hr, detorsion was performed. The Johnson's score, mean seminiferous 
      tubule diameter (MSTD) and height (thickness) of seminiferous tubule epithelium 
      (HST) were significantly increased in TDFP and FP groups as compared to TD group. 
      The gene expression of Bcl-2, level of serum testosterone hormone and antioxidant 
      parameters-GPx and SOD-were significantly higher in TDFP and FP groups than TD 
      group. The index of apoptosis, the gene expression of Bax and the level of MDA 
      were significantly higher in TD group than TDFP and FP groups. Therefore, 
      F. parviflora could decrease oxidative stress induced by testicular 
      torsion-detorsion.
CI  - (c) 2018 Blackwell Verlag GmbH.
FAU - Shokoohi, M
AU  - Shokoohi M
AUID- ORCID: 0000-0001-5197-3740
AD  - Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
AD  - Student Research Committee, Gonabad University of Medical Sciences, Gonabad, 
      Iran.
FAU - Shoorei, H
AU  - Shoorei H
AD  - Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
FAU - Soltani, M
AU  - Soltani M
AD  - Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical 
      Sciences, Gonabad, Iran.
FAU - Abtahi-Eivari, S-H
AU  - Abtahi-Eivari SH
AD  - Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical 
      Sciences, Gonabad, Iran.
FAU - Salimnejad, R
AU  - Salimnejad R
AD  - Research Laboratory for Embryology and Stem Cells, Department of Anatomical 
      Sciences and Pathology, School of Medicine, Ardabil University of Medical 
      Sciences, Ardabil, Iran.
FAU - Moghimian, M
AU  - Moghimian M
AUID- ORCID: 0000-0001-9181-3477
AD  - Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical 
      Sciences, Gonabad, Iran.
LA  - eng
GR  - Deputy of Research and Technology and Student Research Committee of Gonabad 
      University of Medical Sciences/
PT  - Journal Article
DEP - 20180516
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Antioxidants)
RN  - 0 (Bax protein, rat)
RN  - 0 (Plant Extracts)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 3K9958V90M (Ethanol)
RN  - 3XMK78S47O (Testosterone)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology/therapeutic use
MH  - Apoptosis/drug effects
MH  - Disease Models, Animal
MH  - Ethanol/chemistry
MH  - Fumaria/*chemistry
MH  - Humans
MH  - Male
MH  - Malondialdehyde/blood
MH  - Oxidative Stress/*drug effects
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Seminiferous Tubules/drug effects/pathology
MH  - Spermatic Cord Torsion/complications
MH  - Spermatozoa/drug effects
MH  - Testicular Diseases/blood/*drug therapy/etiology/pathology
MH  - Testosterone/blood
MH  - Treatment Outcome
MH  - bcl-2-Associated X Protein/metabolism
OTO - NOTNLM
OT  - Fumaria parviflora
OT  - apoptosis
OT  - oxidative stress markers
OT  - testicular torsion-detorsion
EDAT- 2018/05/18 06:00
MHDA- 2019/06/07 06:00
CRDT- 2018/05/18 06:00
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2019/06/07 06:00 [medline]
PHST- 2018/05/18 06:00 [entrez]
AID - 10.1111/and.13047 [doi]
PST - ppublish
SO  - Andrologia. 2018 Sep;50(7):e13047. doi: 10.1111/and.13047. Epub 2018 May 16.