PMID- 29771025
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181202
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 30
IP  - 9
DP  - 2016 May 5
TI  - [Study on anti-oxidase in smoking-related laryngeal squamous cell carcinoma].
PG  - 733-736
LID - 10.13201/j.issn.1001-1781.2016.09.016 [doi]
AB  - Objective:To investigate the role of oxidative stress in smoking-related 
      laryngeal squamous carcinoma through detecting the expression of antioxidant 
      enzymes in smoking patients. Method:A total of 138 cases with laryngeal squamous 
      cell carcinoma enrolled in the first hospital affiliated the northern he bei 
      college from 2012 to 2015 and forty five volunteers were conducted. All 
      participants were divided into three groups according to smoking index: group 
      A(heavy smoking, 88 cases of laryngeal cancer patients) and group B(no smoking 50 
      cases of laryngeal cancer patients) and C group(45 heavy smoking 
      volunteers).Catalase(CAT), glutathione peroxidase(GSH-px) and 
      malondialdehyde(MDA) and the expression of NRF2 in serum, tissue adjacent to 
      carcinoma, and carcinoma tissues from each groups were measured, respectively. 
      Result:1 in circlethe expression of the CAT and GSH-px in group A were significantly lower 
      than that of group B(P <0.05), but higher than that of group C(P <0.05); 2 in circlethe MDA 
      level of group A is significantly higher than group B(P <0.05) and C group(P 
      <0.01);3 in circleNRF2 was highly expressed in carcinoma tissues, and the expression level 
      was negatively correlated with degree of carcinoma differentiation (P <0.05). 
      Conclusion:Compared with nonsmoking patients, heavy smoking patients with 
      laryngeal cancer were under more severe oxidative stress. NRF2 expression level 
      in patients with laryngeal squamous cell carcinomas was associated with 
      pathological stage.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Liu, Y C
AU  - Liu YC
AD  - Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital 
      of Hebei North University, Zhangjiakou, 075000, China.
FAU - Wei, J
AU  - Wei J
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Li, Y P
AU  - Li YP
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Li, D
AU  - Li D
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Liu, Y B
AU  - Liu YB
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Xu, G G
AU  - Xu GG
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Xue, G
AU  - Xue G
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Lin, Y T
AU  - Lin YT
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
FAU - Shang, X L
AU  - Shang XL
AD  - square square Department of Otolaryngology-Head and Neck Surgery, the First Affiliated 
      Hospital of Hebei North University, Zhangjiakou, 075000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Antioxidants/metabolism
MH  - Carcinoma, Squamous Cell/*enzymology
MH  - Case-Control Studies
MH  - Catalase/blood/*metabolism
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*enzymology
MH  - Male
MH  - Malondialdehyde/blood/metabolism
MH  - NF-E2-Related Factor 2/blood
MH  - *Oxidative Stress
MH  - Smoking/*adverse effects
OTO - NOTNLM
OT  - antioxidant enzymes
OT  - oxidative stress
OT  - respiratory tract neoplasms
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2016/05/05 00:00
MHDA- 2016/05/05 00:01
CRDT- 2018/05/18 06:00
PHST- 2015/09/19 00:00 [received]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2016/05/05 00:00 [pubmed]
PHST- 2016/05/05 00:01 [medline]
AID - 10.13201/j.issn.1001-1781.2016.09.016 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 5;30(9):733-736. doi: 
      10.13201/j.issn.1001-1781.2016.09.016.