PMID- 29771174
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20190628
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 14
IP  - 6
DP  - 2018
TI  - Signaling and induction of chaperone-mediated autophagy by the endoplasmic 
      reticulum under stress conditions.
PG  - 1094-1096
LID - 10.1080/15548627.2018.1444314 [doi]
AB  - Chaperone-mediated autophagy (CMA), a form of selective autophagy, maintains 
      cellular proteostasis in response to diverse stress conditions. Whether and how 
      endoplasmic reticulum (ER) stress triggers CMA remains elusive. In our recent 
      study, we demonstrate that various types of ER stress activate the CMA pathway 
      via an EIF2AK3/PERK-MAP2K4/MKK4-MAPK14/p38-dependent manner. We term this process 
      ERICA for ER stress-induced chaperone-mediated autophagy. This pathway is 
      activated in response to stress associated with Parkinson disease and is required 
      for the viability of the SNc dopaminergic neurons in an animal model of Parkinson 
      disease.
FAU - Li, Wenming
AU  - Li W
AUID- ORCID: 0000-0002-8396-9110
AD  - a Department of Pharmacology , Emory University School of Medicine , Atlanta , GA 
      , USA.
FAU - Yang, Qian
AU  - Yang Q
AD  - b Department of Neurosurgery, Tangdu Hospital , The Fourth Military Medical 
      University , Xi'an , Shaanxi , China.
FAU - Mao, Zixu
AU  - Mao Z
AD  - a Department of Pharmacology , Emory University School of Medicine , Atlanta , GA 
      , USA.
LA  - eng
GR  - R01 NS095269/NS/NINDS NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180517
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
CON - Nat Commun. 2017 Nov 24;8(1):1763. PMID: 29176575
MH  - Animals
MH  - *Autophagy
MH  - Endoplasmic Reticulum
MH  - *Endoplasmic Reticulum Stress
MH  - Phosphorylation
MH  - p38 Mitogen-Activated Protein Kinases
PMC - PMC6103395
OTO - NOTNLM
OT  - CMA
OT  - ER stress
OT  - PERK
OT  - Parkinson's disease
OT  - p38 MAPK
EDAT- 2018/05/18 06:00
MHDA- 2019/06/30 06:00
PMCR- 2019/05/17
CRDT- 2018/05/18 06:00
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2019/05/17 00:00 [pmc-release]
AID - 1444314 [pii]
AID - 10.1080/15548627.2018.1444314 [doi]
PST - ppublish
SO  - Autophagy. 2018;14(6):1094-1096. doi: 10.1080/15548627.2018.1444314. Epub 2018 
      May 17.