PMID- 29772042
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20220408
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 49
IP  - 5
DP  - 2018 May 1
TI  - Subfoveal Choroidal Thickness as a Potential Predictor of Clinical Response to 
      Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration.
PG  - 320-328
LID - 10.3928/23258160-20180501-05 [doi]
AB  - BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant 
      treatment modality that has been shown to reduce the need for repetitive 
      intravitreal injections (IVIs) in patients with neovascular age-related macular 
      degeneration (nAMD). The authors aimed to determine baseline predictors of 
      clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, 
      observational case series of patients with nAMD who underwent SRT and 
      subsequently had at least 12 months of complete follow-up. After SRT and one 
      mandatory IVI, patients were examined every 4 weeks and received further 
      treatment on a pro re nata basis. Examination included enhanced depth imaging 
      spectral-domain optical coherence tomography (SD-OCT) to measure subfoveal 
      choroidal thickness (SFCT) and central macular thickness (CMT). Patients' data 
      were retrieved from medical records and included demographics, disease duration, 
      lesion size, best-corrected visual acuity (BCVA), previous number of IVIs, and 
      type of drug applied. RESULTS: A total of 35 eyes of 35 patients (76.23 years +/- 
      7.05 years) were included, and 21 eyes (60%) responded well to SRT. The annual 
      injection rate decreased from 6.86 before SRT to 3.46 afterward, whereas BCVA 
      improved from 0.49 logMAR at baseline to 0.37 logMAR at final follow-up. From a 
      morphologic point of view, CMT and SFCT decreased by 71 mum and 37 mum, 
      respectively, at 12-month follow-up compared to baseline. Of all investigated 
      parameters, only SFCT proved to be significant, as a higher baseline SFCT was 
      found to be a strong negative predictor for the number of IVIs needed after SRT 
      (regression coefficient: -0.678; P < .001). CONCLUSIONS: Baseline SFCT may help 
      predict which patients with nAMD will respond more favorably to SRT. The authors 
      found eyes with a thicker baseline SFCT needed fewer IVIs after SRT. [Ophthalmic 
      Surg Lasers Imaging Retina. 2018;49:320-328.].
CI  - Copyright 2018, SLACK Incorporated.
FAU - Ranjbar, Mahdy
AU  - Ranjbar M
FAU - Kurz, Maximilian
AU  - Kurz M
FAU - Holzhey, Annekatrin
AU  - Holzhey A
FAU - Rades, Dirk
AU  - Rades D
FAU - Grisanti, Salvatore
AU  - Grisanti S
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/pathology/*radiation effects
MH  - Choroidal Neovascularization/*radiotherapy
MH  - Female
MH  - Humans
MH  - Macular Degeneration/pathology/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Radiosurgery/*methods
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2018/05/18 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/05/18 06:00
PHST- 2017/06/25 00:00 [received]
PHST- 2017/11/01 00:00 [accepted]
PHST- 2018/05/18 06:00 [entrez]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
AID - 10.3928/23258160-20180501-05 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2018 May 1;49(5):320-328. doi: 
      10.3928/23258160-20180501-05.