PMID- 29772442
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 104
DP  - 2018 Aug
TI  - Cognitive and hippocampus biochemical changes following sleep deprivation in the 
      adult male rat.
PG  - 69-76
LID - S0753-3322(18)30421-9 [pii]
LID - 10.1016/j.biopha.2018.04.197 [doi]
AB  - Sleep deprivation (SD) influences physiological processes such as cognitive 
      function. The balance of oxidant and antioxidant markers, neurotrophic factors 
      and magnesium are affected by sleep deprivation but there is no difference 
      between pre and post training sleep deprivation. This study was designed to 
      investigate memory retrieval and biochemical factors such as oxidant and 
      antioxidant enzyme, brain-derived neurotrophic factor (BDNF) and magnesium levels 
      in the hippocampus following pre and post-training sleep deprivation. Male Wistar 
      rats (weighing 200 +/- 20 g) in below groups were used: control 1, 24, 48 and 72 h 
      SD before training groups, control2, 24 h SD1 after training (being evaluated 
      24 h after training) and SD2 24 after training (being evaluated 48 h after 
      training). Memory was evaluated 90 min, 24 h or 48 h after training by 
      step-through passive avoidance apparatus. Multiple platforms method was used to 
      induce SD. Oxidant and antioxidant markers including glutathione (GSH), 
      glutathione reductase (GPx), malonedialdehyde (MDA), Total antioxidant 
      concentration, catalase, superoxide dismutase (SOD), magnesium and BDNF were 
      assessed in the hippocampus or/and brain. 72 h pre-training SD impaired short and 
      long-term memory significantly. There was no significant difference in 
      hippocampus oxidant and antioxidant markers compared to control. Hippocampal BDNF 
      and magnesium did not show any changes in all SD groups. Lack of correlation 
      between memory impairment and levels of BDNF, magnesium and/or oxidant and 
      antioxidant balance in the hippocampus is likely to be related to animal 
      locomotor activity in the multiple platforms method. More research is needed to 
      clarify the role of neurochemical systems.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Nabaee, Ebrahim
AU  - Nabaee E
AD  - Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran. Electronic address: e-nabaee@phdstu.scu.ac.ir.
FAU - Kesmati, Mahnaz
AU  - Kesmati M
AD  - Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Shahriari, Ali
AU  - Shahriari A
AD  - ِDepartment of Biochemistry, Faculty of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
FAU - Khajehpour, Lotfollah
AU  - Khajehpour L
AD  - Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
FAU - Torabi, Mozhgan
AU  - Torabi M
AD  - Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180514
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Catalase/metabolism
MH  - Cognition/*physiology
MH  - Glutathione/metabolism
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Memory Disorders/metabolism
MH  - Oxidative Stress/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Sleep Deprivation/*metabolism
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Magnesium
OT  - Memory
OT  - Oxidative stress
OT  - Sleep deprivation
EDAT- 2018/05/18 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/05/18 06:00
PHST- 2018/02/10 00:00 [received]
PHST- 2018/04/26 00:00 [revised]
PHST- 2018/04/29 00:00 [accepted]
PHST- 2018/05/18 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/05/18 06:00 [entrez]
AID - S0753-3322(18)30421-9 [pii]
AID - 10.1016/j.biopha.2018.04.197 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Aug;104:69-76. doi: 10.1016/j.biopha.2018.04.197. Epub 
      2018 May 14.