PMID- 29772691 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240326 IS - 2079-4991 (Print) IS - 2079-4991 (Electronic) IS - 2079-4991 (Linking) VI - 8 IP - 5 DP - 2018 May 16 TI - Periodontal Tissues, Maxillary Jaw Bone, and Tooth Regeneration Approaches: From Animal Models Analyses to Clinical Applications. LID - 10.3390/nano8050337 [doi] LID - 337 AB - This review encompasses different pre-clinical bioengineering approaches for periodontal tissues, maxillary jaw bone, and the entire tooth. Moreover, it sheds light on their potential clinical therapeutic applications in the field of regenerative medicine. Herein, the electrospinning method for the synthesis of polycaprolactone (PCL) membranes, that are capable of mimicking the extracellular matrix (ECM), has been described. Furthermore, their functionalization with cyclosporine A (CsA), bone morphogenetic protein-2 (BMP-2), or anti-inflammatory drugs' nanoreservoirs has been demonstrated to induce a localized and targeted action of these molecules after implantation in the maxillary jaw bone. Firstly, periodontal wound healing has been studied in an induced periodontal lesion in mice using an ibuprofen-functionalized PCL membrane. Thereafter, the kinetics of maxillary bone regeneration in a pre-clinical mouse model of surgical bone lesion treated with BMP-2 or BMP-2/Ibuprofen functionalized PCL membranes have been analyzed by histology, immunology, and micro-computed tomography (micro-CT). Furthermore, the achievement of innervation in bioengineered teeth has also been demonstrated after the co-implantation of cultured dental cell reassociations with a trigeminal ganglia (TG) and the cyclosporine A (CsA)-loaded poly(lactic-co-glycolic acid) (PLGA) scaffold in the jaw bone. The prospective clinical applications of these different tissue engineering approaches could be instrumental in the treatment of various periodontal diseases, congenital dental or cranio-facial bone anomalies, and post-surgical complications. FAU - Batool, Fareeha AU - Batool F AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. s_fareeha_b@hotmail.com. FAU - Strub, Marion AU - Strub M AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. marion.strub@chru-strasbourg.fr. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. marion.strub@chru-strasbourg.fr. AD - Departement of Pediatric Dentistry, Pole de Medecine et Chirurgie Bucco-Dentaires, Hopitaux Universitaires de Strasbourg (HUS), 1 place de l'Hopital, 67000 Strasbourg, France. marion.strub@chru-strasbourg.fr. FAU - Petit, Catherine AU - Petit C AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. catherin.petit@gmail.com. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. catherin.petit@gmail.com. AD - Department of Periodontology, Pole de Medecine et Chirurgie Bucco-Dentaires, Hopitaux Universitaires de Strasbourg (HUS), 1 place de l'Hopital, 67000 Strasbourg, France. catherin.petit@gmail.com. FAU - Bugueno, Isaac Maximiliano AU - Bugueno IM AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. isaacmaxi@gmail.com. FAU - Bornert, Fabien AU - Bornert F AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. fabien.bornert@chru-strasbourg.fr. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. fabien.bornert@chru-strasbourg.fr. AD - Department of Oral Surgery, Pole de Medecine et Chirurgie Bucco-Dentaires, Hopitaux Universitaires de Strasbourg (HUS), 1 place de l'Hopital, 67000 Strasbourg, France. fabien.bornert@chru-strasbourg.fr. FAU - Clauss, Francois AU - Clauss F AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. francois.clauss@chru-strasbourg.fr. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. francois.clauss@chru-strasbourg.fr. AD - Departement of Pediatric Dentistry, Pole de Medecine et Chirurgie Bucco-Dentaires, Hopitaux Universitaires de Strasbourg (HUS), 1 place de l'Hopital, 67000 Strasbourg, France. francois.clauss@chru-strasbourg.fr. FAU - Huck, Olivier AU - Huck O AUID- ORCID: 0000-0002-7988-2290 AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. o.huck@unistra.fr. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. o.huck@unistra.fr. AD - Department of Periodontology, Pole de Medecine et Chirurgie Bucco-Dentaires, Hopitaux Universitaires de Strasbourg (HUS), 1 place de l'Hopital, 67000 Strasbourg, France. o.huck@unistra.fr. FAU - Kuchler-Bopp, Sabine AU - Kuchler-Bopp S AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. kuchler@unistra.fr. FAU - Benkirane-Jessel, Nadia AU - Benkirane-Jessel N AD - INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative NanoMedicine (RNM), FMTS, 67000 Strasbourg, France. nadia.jessel@inserm.fr. AD - Faculty of Dentistry, University of Strasbourg (UDS), 8 rue Ste Elisabeth, 67000 Strasbourg, France. nadia.jessel@inserm.fr. LA - eng PT - Journal Article PT - Review DEP - 20180516 PL - Switzerland TA - Nanomaterials (Basel) JT - Nanomaterials (Basel, Switzerland) JID - 101610216 PMC - PMC5977351 OTO - NOTNLM OT - BMP-2 OT - bioengineered tooth OT - cyclosporine A OT - electrospun polycaprolactone OT - ibuprofen OT - innervation OT - nanoreservoirs OT - periodontitis COIS- The authors declare no conflict of interest with respect to the authorship and/or publications of this article. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2018/05/19 06:00 MHDA- 2018/05/19 06:01 PMCR- 2018/05/16 CRDT- 2018/05/19 06:00 PHST- 2018/04/24 00:00 [received] PHST- 2018/05/14 00:00 [revised] PHST- 2018/05/15 00:00 [accepted] PHST- 2018/05/19 06:00 [entrez] PHST- 2018/05/19 06:00 [pubmed] PHST- 2018/05/19 06:01 [medline] PHST- 2018/05/16 00:00 [pmc-release] AID - nano8050337 [pii] AID - nanomaterials-08-00337 [pii] AID - 10.3390/nano8050337 [doi] PST - epublish SO - Nanomaterials (Basel). 2018 May 16;8(5):337. doi: 10.3390/nano8050337.