PMID- 29773049 OWN - NLM STAT- MEDLINE DCOM- 20190709 LR - 20190709 IS - 1940-4379 (Electronic) IS - 1050-6934 (Linking) VI - 27 IP - 2-4 DP - 2017 TI - An Update on the Global Epidemic of Human T-Cell Lymphotrophic Virus Type-I (HTLV-I). PG - 355-368 LID - 10.1615/JLongTermEffMedImplants.v27.i2-4.160 [doi] AB - Infection with human T-cell lymphotrophic virus-I (HTLV-I) is now a global epidemic, affecting 10 to 20 million people. This virus has been linked to life-threatening, incurable diseases, adult T-cell leukemia/lymphoma (ATLL), and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as several chronic illnesses, such as uveitis and dermatitis. The cumulative lifetime risk of developing these incurable diseases is approximately 5% in asymptomatic patients. For operating room personnel performing surgery among patients from high-risk groups, HTLV-I and its associated diseases are presenting an increasing challenge. This report describes its transmission, seroprevalence, treatment, and public health initiatives that must be instituted to prevent the spread of this retrovirus. Coinfection with HTLV-I and human immunodeficiency virus (HIV) has been shown to accelerate the progression of acquired immune deficiency syndrome (AIDS). FAU - Edlich, Richard AU - Edlich R AD - Legacy Verified Level I Shock Trauma Center Pediatrics and Adults, Legacy Emanual Hospital; and Plastic Surgery, Biomedical Engineering and Emergency Medicine, University of Virginia Health System, USA. FAU - Hill, Lisa G AU - Hill LG AD - Plastic Surgery Research Program, University of Virginia Health System, Charlottesville, Virginia. FAU - Williams, Freddie M AU - Williams FM AD - Harvard Medical School, Boston, Massachusetts. LA - eng PT - Journal Article PL - United States TA - J Long Term Eff Med Implants JT - Journal of long-term effects of medical implants JID - 9110830 MH - Dermatitis/virology MH - *Epidemics MH - Global Health MH - HTLV-I Infections/*epidemiology/transmission MH - *Human T-lymphotropic virus 1 MH - Humans MH - Infectious Disease Transmission, Patient-to-Professional/prevention & control MH - Leukemia-Lymphoma, Adult T-Cell/virology MH - Occupational Diseases/prevention & control/virology MH - Paraparesis, Tropical Spastic/virology MH - Public Health MH - Seroepidemiologic Studies MH - Uveitis/virology EDAT- 2017/01/01 00:00 MHDA- 2019/07/10 06:00 CRDT- 2018/05/19 06:00 PHST- 2018/05/19 06:00 [entrez] PHST- 2017/01/01 00:00 [pubmed] PHST- 2019/07/10 06:00 [medline] AID - 653bafd45309845f,1b889c2e592f466b [pii] AID - 10.1615/JLongTermEffMedImplants.v27.i2-4.160 [doi] PST - ppublish SO - J Long Term Eff Med Implants. 2017;27(2-4):355-368. doi: 10.1615/JLongTermEffMedImplants.v27.i2-4.160.