PMID- 29773978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 12
DP  - 2018
TI  - Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in 
      Offspring Rats: Beneficial Effects of Maternal Exercise.
PG  - 122
LID - 10.3389/fncel.2018.00122 [doi]
LID - 122
AB  - Fetal exposure to general anesthetics may pose significant neurocognitive risks 
      but methods to mitigate against these detrimental effects are still to be 
      determined. We set out, therefore, to assess whether single or repeated in utero 
      exposure to sevoflurane triggers long-term cognitive impairments in rat 
      offspring. Since maternal exercise during pregnancy has been shown to improve 
      cognition in offspring, we hypothesized that maternal treadmill exercise during 
      pregnancy would protect against sevoflurane-induced neurotoxicity. In the first 
      experiment, pregnant rats were exposed to 3% sevoflurane for 2 h on gestational 
      (G) day 14, or to sequential exposure for 2 h on G13, G14 and G15. In the second 
      experiment, pregnant rats in the exercise group were forced to run on a treadmill 
      for 60 min/day during the whole pregnancy. The TrkB antagonist ANA-12 was used to 
      investigate whether the brain-derived neurotrophic factor (BDNF)/TrkB/Akt 
      signaling pathway is involved in the neuroprotection afforded by maternal 
      exercise. Our data suggest that repeated, but not single, exposure to sevoflurane 
      caused a reduction in both histone acetylation and BDNF expression in fetal brain 
      tissues and postnatal hippocampus. This was accompanied by decreased numbers of 
      dendritic spines, impaired spatial-dependent learning and memory dysfunction. 
      These effects were mitigated by maternal exercise but the TrkB antagonist ANA-12 
      abolished the beneficial effects of maternal exercise. Our findings suggest that 
      repeated, but not single, exposure to sevoflurane in pregnant rats during the 
      second trimester caused long-lasting learning and memory dysfunction in the 
      offspring. Maternal exercise ameliorated the postnatal neurocognitive impairment 
      by enhancing histone acetylation and activating downstream BDNF/TrkB/Akt 
      signaling.
FAU - Wu, Ziyi
AU  - Wu Z
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Li, Xingyue
AU  - Li X
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Tong, Dongyi
AU  - Tong D
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Wang, Lili
AU  - Wang L
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Zhao, Ping
AU  - Zhao P
AD  - Department of Anesthesiology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20180503
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC5943573
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - general anesthesia
OT  - learning and memory
OT  - maternal exercise
OT  - mid-pregnancy
EDAT- 2018/05/19 06:00
MHDA- 2018/05/19 06:01
PMCR- 2018/01/01
CRDT- 2018/05/19 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/04/16 00:00 [accepted]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/05/19 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2018.00122 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2018 May 3;12:122. doi: 10.3389/fncel.2018.00122. 
      eCollection 2018.