PMID- 29774145
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 8
IP  - 6
DP  - 2018 Jun
TI  - Evaluation of attenuative effect of tert-butylhydroquinone against 
      diazinon-induced oxidative stress on hematological indices in male Wistar rats.
PG  - 565-570
LID - 10.3892/br.2018.1090 [doi]
AB  - Diazinon is an organophosphate toxicant that has been identified to induce 
      oxidative stress within biological systems through altering biochemical and 
      hematological indices, by generating free radicals while deteriorating the 
      cellular antioxidant defense system. The present study was designed to evaluate 
      the effectiveness of tert-butylhydroquinone (TBHQ), a synthetic food additive, in 
      serving as an antioxidant against sub-lethal diazinon-induced oxidative stress in 
      male Wistar rats. Animals were randomly divided into 4 groups: Control (treated 
      with corn oil as a vehicle), diazinon (10 mg/kg/day), TBHQ (0.028 g/kg of diet) 
      and a combination group of TBHQ (0.028 g/kg of diet) plus diazinon (10 
      mg/kg/day). All animals were treated orally once a day by gastric tube and 
      treatments were continued for 7 weeks. Hematological indices, including red blood 
      cell (RBC) indices and white blood cell (WBC) and platelet counts, were measured 
      at the end of the treatment schedule. On comparison of the treatment groups with 
      the untreated control group, RBC count, hemoglobin (Hb), hematocrit (Hct), mean 
      corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) 
      were significantly decreased in the diazinon and TBHQ+diazinon groups, while MCHC 
      in the TBHQ group and MCV in the diazinon and TBHQ+diazinon groups were 
      significantly increased. When the diazinon and TBHQ+diazinon groups were compared 
      with the TBHQ group, RBC, Hb, Hct, and MCHC were significantly decreased whereas 
      MCV was increased in both groups. Additionally, when comparing the TBHQ+diazinon 
      group with the diazinon group, MCHC was determined to be significantly decreased. 
      The results of the current experiments suggested that TBHQ could not efficiently 
      protect blood cells against diazinon toxicity.
FAU - Sargazi, Saman
AU  - Sargazi S
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University 
      of Mashhad, Mashhad, Razavi Khorasan 9177948974, Iran.
AD  - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, 
      Zahedan, Sistan and Baluchestan 9816743181, Iran.
FAU - Galavi, Hamidreza
AU  - Galavi H
AD  - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, 
      Zahedan, Sistan and Baluchestan 9816743181, Iran.
FAU - Zarei, Sadegh
AU  - Zarei S
AD  - Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi 
      University of Medical Sciences, Yazd 8916978477, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180423
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC5954602
OTO - NOTNLM
OT  - diazinon
OT  - organophosphate
OT  - pesticide
OT  - tert-butylhydroquinone
EDAT- 2018/05/19 06:00
MHDA- 2018/05/19 06:01
PMCR- 2018/04/23
CRDT- 2018/05/19 06:00
PHST- 2018/02/16 00:00 [received]
PHST- 2018/04/19 00:00 [accepted]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/05/19 06:01 [medline]
PHST- 2018/04/23 00:00 [pmc-release]
AID - BR-0-0-1090 [pii]
AID - 10.3892/br.2018.1090 [doi]
PST - ppublish
SO  - Biomed Rep. 2018 Jun;8(6):565-570. doi: 10.3892/br.2018.1090. Epub 2018 Apr 23.