PMID- 29774395
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181202
IS  - 1439-099X (Electronic)
IS  - 0179-7158 (Linking)
VI  - 194
IP  - 10
DP  - 2018 Oct
TI  - Early versus late prophylactic cranial irradiation in patients with extensive 
      small cell lung cancer.
PG  - 876-885
LID - 10.1007/s00066-018-1307-1 [doi]
AB  - OBJECTIVE: Previous studies demonstrated that prophylactic cranial irradiation 
      (PCI) significantly reduced the incidence of brain metastases in patients with 
      extensive disease small cell lung cancer (ED-SCLC). However, the appropriate 
      timing for PCI in treating ED-SCLC is still unclear. This study aimed to compare 
      the effect and safety of early versus late PCI. METHODS: Between November 2011 
      and July 2016, 103 patients with ED-SCLC were reviewed, receiving appropriate 
      imaging tests to exclude brain metastases prior to cranial irradiation. Of these 
      103 patients, early PCI was performed in 47 patients and the other 56 patients 
      received late PCI. The primary endpoint was the incidence of brain metastases. 
      The progression-free survival (PFS), overall survival (OS), and adverse events 
      (AEs) were also assessed. RESULTS: Early PCI significantly lowered the risk of 
      brain metastases, as compared to late PCI (p = 0.024). Additionally, multivariate 
      analyses demonstrated that early PCI was a favorable independent predictor of the 
      incidence of brain metastases. The PFS and OS of patients in the early and late 
      PCI groups were comparable (PFS: 8.4 months vs. 7.5 months, p = 0.234; OS: 
      16.1 months vs. 15.2 months, p = 0.753). The AEs were generally acceptable in 
      both groups. CONCLUSION: To reduce the incidence of brain metastases, early PCI 
      is more effective than late PCI for ED-SCLC patients.
FAU - Chen, Yi
AU  - Chen Y
AD  - School of Clinical Medicine, Tsinghua University, Beijing, China.
FAU - Li, Jinyu
AU  - Li J
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Zhang, Yibao
AU  - Zhang Y
AD  - Department of Radiotherapy, Peking University Cancer Hospital & Institute, Key 
      Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Beijing, China.
FAU - Hu, Yi
AU  - Hu Y
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Zhang, Guoqing
AU  - Zhang G
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Yan, Xiang
AU  - Yan X
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Lin, Zhi
AU  - Lin Z
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Zhao, Zhifei
AU  - Zhao Z
AD  - Department of Radiation Oncology, Chinese PLA General Hospital, Beijing, China.
FAU - Jiao, Shunchang
AU  - Jiao S
AUID- ORCID: 0000-0002-0910-4223
AD  - Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China. 
      jiaosc_301pla@163.com.
AD  - , 28 Fu Xing Road, Haidian District, 100853, Beijing, China. 
      jiaosc_301pla@163.com.
LA  - eng
GR  - 11505012/National Natural Science Foundation of China/
GR  - 7172048/Beijing Municipal Natural Science Foundation/
GR  - QML20151004/Beijing Municipal administration of hospitals' youth program/
PT  - Comparative Study
PT  - Journal Article
TT  - Fruhe vs. spate prophylaktische kraniale Bestrahlung bei Patienten mit 
      metastasiertem kleinzelligem Lungenkarzinom.
DEP - 20180517
PL  - Germany
TA  - Strahlenther Onkol
JT  - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et 
      al]
JID - 8603469
SB  - IM
MH  - Aged
MH  - Brain Neoplasms/pathology/*prevention & control/*secondary
MH  - Carcinoma, Small Cell/pathology/*prevention & control/*secondary
MH  - Combined Modality Therapy
MH  - *Cranial Irradiation/adverse effects
MH  - Disease-Free Survival
MH  - Dose Fractionation, Radiation
MH  - *Early Medical Intervention
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lung Neoplasms/pathology/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Intensity-Modulated
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Chemotherapy
OT  - Dose fractionation
OT  - Metastases
OT  - Radiotherapy
OT  - Small cell lung carcinoma
EDAT- 2018/05/19 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/05/19 06:00
PHST- 2017/06/21 00:00 [received]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/05/19 06:00 [entrez]
AID - 10.1007/s00066-018-1307-1 [pii]
AID - 10.1007/s00066-018-1307-1 [doi]
PST - ppublish
SO  - Strahlenther Onkol. 2018 Oct;194(10):876-885. doi: 10.1007/s00066-018-1307-1. 
      Epub 2018 May 17.