PMID- 29774995
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181004
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 31
IP  - 11
DP  - 2017 Jun 5
TI  - [Study on the relationship between MCT-1 and p53 in laryngeal squamous cell 
      carcinoma].
PG  - 825-829
LID - 10.13201/j.issn.1001-1781.2017.11.003 [doi]
AB  - Objective:The aim of this study is to investigate the expression and clinical 
      significance of monocarboxylate transporter 1 (MCT-1) and p53 in laryngeal 
      squamous cell carcinoma (LSCC). Method:Immunohistochemical staining of MCT-1 and 
      p53 was carried out in 41 cases of laryngeal squamous cell carcinoma embedded in 
      paraffin, and the relationship between positive expression and 
      clinicopathological data was evaluated. All data were analyzed by SPSS software 
      (Windows version 21.0). Result:In normal mucosa p53 expression was absent; while, 
      the basal "stem cell" layer is highly enriched in MCT-1. The positive expression 
      of MCT-1 and p53 in the 41 cases of LSCC was 73.2% and 61.0% respectively. The 
      differential expressions of MCT-1 and p53 in LSCC and normal tissues had 
      significant difference (P=0.002, P=0.028). In the well-differentiated tumor 
      tissues, MCT-1 was mainly expressed in the highly invasive cancerous cells. In 
      poorly differentiated tumors, cells in the nests diffusely stain strongly for 
      MCT-1. Of the 41 cases of LSCC, MCT-1 and p53 was significantly associated with 
      histologic grade (P=0.046, P=0.047), clinical stage (P=0.023, P=0.044) and lymph 
      node metastasis (P=0.044, P=0.005). However, over expression of MCT-1 and p53 had 
      no relation with age (P=0.945, P=0.364), gender (P=1.0, P=1.0) and tumor location 
      (P=0.456, P=0.51). Spearman analysis is shown a positive correlation with MCT-1 
      and p53 (r=0.418, P=0.006). Conclusion:MCT-1 is an importer of L-lactate and 
      ketone bodies into cells, and high expression of MCT-1 induces high OXPHOS and 
      low glycolytic states. We show here that MCT-1 is the best marker of the basal 
      stem cell layer of normal mucosa, and its expression correlate with high p53 
      expression in LSCC. Therefore, MCT-1 is a new target for the development of 
      anticancer drugs for laryngeal squamous cell carcinoma.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Wang, Y B
AU  - Wang YB
AD  - Department of Otolaryngology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
FAU - Xu, O
AU  - Xu O
AD  - Department of Otolaryngology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
FAU - Zhang, R J
AU  - Zhang RJ
AD  - Department of Otolaryngology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
FAU - Shan, C G
AU  - Shan CG
AD  - Department of Otolaryngology, the Second Hospital of Hebei Medical University, 
      Shijiazhuang, 050000, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Monocarboxylic Acid Transporters)
RN  - 0 (Symporters)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (monocarboxylate transport protein 1)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Head and Neck Neoplasms
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Monocarboxylic Acid Transporters/genetics/*metabolism
MH  - Prognosis
MH  - Symporters/genetics/*metabolism
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
OTO - NOTNLM
OT  - immunohistochemistry
OT  - laryngeal neoplasms
OT  - monocarboxylate transporter-1
OT  - p53
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/19 06:00
MHDA- 2018/05/19 06:01
CRDT- 2018/05/19 06:00
PHST- 2017/01/17 00:00 [received]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/05/19 06:01 [medline]
AID - 10.13201/j.issn.1001-1781.2017.11.003 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):825-829. doi: 
      10.13201/j.issn.1001-1781.2017.11.003.