PMID- 29774997
OWN - NLM
STAT- MEDLINE
DCOM- 20181004
LR  - 20181004
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 31
IP  - 11
DP  - 2017 Jun 5
TI  - [The significance of lymphocyte to monocyte ratio in peripheral blood of patients 
      with benign and malignant laryngeal lesions].
PG  - 835-838
LID - 10.13201/j.issn.1001-1781.2017.11.005 [doi]
AB  - Objective:The aim of this study is to investigate the value of preoperative 
      peripheral blood lymphocyte to monocyte ratio (LMR) in differentiating laryngeal 
      squamous cell carcinoma (LSCC), laryngeal precancerous lesions (LPL) and 
      laryngeal benign lesions (LBL). Method:Four hundred and five cases of laryngeal 
      lesions diagnosed by pathology (154 cases of LSCC, 83 cases of LPL and 168 cases 
      of LBL) were collected. LSCC group was further divided into T1 group, T2 group 
      and T3-4 group based on T stage. The levels of neutrophils, lymphocytes, 
      monocytes, hemoglobin, platelet and other blood indexes were measured, as well as 
      compared the LMR, neutrophil to lymphocyte ratio (NLR) and other parameters in 
      each group. Result:The LMR and NLR in LBL, LPL and LSCC groups was 4.88+/-1.65 and 
      4.61+/-1.59, 3.92+/-1.77 and 2.11+/-0.79, 2.08+/-0.77 and 2.63+/-1.69, respectively. The 
      LMR in the LSCC group was significantly lower than those in the LBL and LPL group 
      (P<0.01), whereas the NLR was significantly higher than those in LBL and LPL 
      group (P<0.05). Either LMR or NLR between the LBL and LPL group was not 
      statistically different (P>0.05). The LMR of patients with local advanced (T3-4) 
      stage in the LSCC group was lower than that in the early or medium stage (T1-2), 
      while the NLR was higher and the difference was statistically significant 
      (P<0.05). There was no significant difference in platelet, white blood cell and 
      neutrophil count between LBL, LPL and LSCC (P>0.05). Conclusion:We, for the first 
      time, compared LMR in different laryngeal lesions and found that LMR and NLR as a 
      systemic inflammatory index have a certain reference value for to differentiate 
      LSCC from LPL and LBL.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Wu, D Q
AU  - Wu DQ
AD  - Department of Otolaryngology Head and Neck Surgery, Zhongshan Hospital Affiliated 
      to Fudan University, Shanghai, 200032, China.
FAU - Huang, X S
AU  - Huang XS
AD  - Department of Otolaryngology Head and Neck Surgery, Zhongshan Hospital Affiliated 
      to Fudan University, Shanghai, 200032, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
SB  - IM
MH  - Carcinoma, Squamous Cell/*blood/diagnosis
MH  - Humans
MH  - Laryngeal Diseases/blood/diagnosis
MH  - Laryngeal Neoplasms/*blood/diagnosis
MH  - Lymphocyte Count
MH  - Lymphocytes/*cytology
MH  - Monocytes/*cytology
MH  - Neutrophils/*cytology
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - laryngeal benign lesion
OT  - laryngeal neoplasms
OT  - laryngeal precancerous lesion
OT  - lymphocyte to monocyte ratio
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/19 06:00
MHDA- 2018/05/19 06:01
CRDT- 2018/05/19 06:00
PHST- 2017/04/05 00:00 [received]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/05/19 06:01 [medline]
AID - 10.13201/j.issn.1001-1781.2017.11.005 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jun 5;31(11):835-838. doi: 
      10.13201/j.issn.1001-1781.2017.11.005.