PMID- 29775019
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 3
DP  - 2018 Feb
TI  - [The expression and clinical progression of androgen, estrogen and prolactin 
      receptor in laryngeal squamous cell carcinoma].
PG  - 190-195
LID - 10.13201/j.issn.1001-1781.2018.03.008 [doi]
AB  - Objective:The aim of this study is to analyze the different expression and 
      function of androgen receptors (AR) and estrogen receptor (ER-alpha) in laryngeal 
      squamous cell carcinoma (LSCC). In combination with the expression of prolactin 
      receptor (PRLR), we analyzed the prognostic impact of three receptors on the 
      laryngeal carcinoma. Method:In this study, immunohistochemistry and reverse 
      transcription polymerase chain reaction (RT-PC) analysis were performed on the 
      tumor tissues and adjacent normal tissues in 112 LSCC patients (95 males and 17 
      females). We found that hormone receptor expression is closely related to the 
      clinical tumor lesions and overall survival data. Result:The expression of AR, 
      ER-alpha and PRLR in tumor tissues were much higher than those in adjacent normal 
      tissues (P>0.05) at both protein and mRNA levels. The higher PRLR level indicate 
      poor survival in LSCC patients (P=0.02), while higher ER-alpha expression could 
      influence the survival with considerable trend toward significance (P=0.06). 
      Furthermore, the higher expression of ER-alpha in tumours were corresponding with 
      PRLR cytoplasmic higher level expression (r=0.802, P=0.04). This mutual promoted 
      effect between ER-alpha and PRLR possibly suggests potential mechanisms among those 
      sex related hormone receptors in laryngeal cancer. Conclusion:It has become 
      increasingly credible that the sex related hormone receptors play an important 
      role in the development of LSCC.
FAU - Fei, M J
AU  - Fei MJ
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
FAU - Xu, Y N
AU  - Xu YN
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
FAU - Wang, J D
AU  - Wang JD
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Receptors, Androgen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Prolactin)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Prognosis
MH  - Receptors, Androgen/*metabolism
MH  - Receptors, Estrogen/*metabolism
MH  - Receptors, Prolactin/*metabolism
OTO - NOTNLM
OT  - androgen receptor
OT  - estrogen receptor alpha
OT  - laryngeal neoplasms
OT  - overall survival
OT  - prolactin receptor
EDAT- 2018/05/19 06:00
MHDA- 2018/05/19 06:01
CRDT- 2018/05/19 06:00
PHST- 2017/09/18 00:00 [received]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/05/19 06:01 [medline]
AID - 10.13201/j.issn.1001-1781.2018.03.008 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Feb;32(3):190-195. doi: 
      10.13201/j.issn.1001-1781.2018.03.008.