PMID- 29775542
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 11
DP  - 2018 Nov
TI  - Exercise and circulating BDNF: Mechanisms of release and implications for the 
      design of exercise interventions.
PG  - 1095-1104
LID - 10.1139/apnm-2018-0192 [doi]
AB  - Engagement in regular bouts of exercise confers numerous positive effects on 
      brain health across the lifespan. Acute bouts of exercise transiently improve 
      cognitive function, while long-term exercise training stimulates brain 
      plasticity, improves brain function, and helps to stave off neurological disease. 
      The action of brain-derived neurotrophic factor (BDNF) is a candidate mechanism 
      underlying these exercise-induced benefits and is the subject of considerable 
      attention in the exercise-brain health literature. It is well established that 
      acute exercise increases circulating levels of BDNF and numerous studies have 
      sought to characterize this response for the purpose of improving brain health. 
      Despite the interest in BDNF responses to exercise, little focus has been given 
      to understanding the sources and mechanisms that underlie this response for the 
      purpose of deliberately increasing circulating levels of BDNF. Here we review 
      evidence to support that exploiting these mechanisms of BDNF release can help to 
      optimize brain plasticity outcomes via exercise interventions, which could be 
      especially relevant in the context of multimodal training (i.e., exercise and 
      cognitive stimulation). Therefore, the purpose of this paper is to review the 
      candidate sources of BDNF during exercise and the mechanisms of release. As well, 
      we discuss strategies for maximizing BDNF responses to exercise, and propose 
      novel research directions for advancing our understanding of these mechanisms.
FAU - Walsh, Jeremy J
AU  - Walsh JJ
AD  - a Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, 
      Canada.
FAU - Tschakovsky, Michael E
AU  - Tschakovsky ME
AD  - b School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 
      3N6, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180518
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Brain-Derived Neurotrophic Factor/blood/metabolism/physiology
MH  - Exercise/*physiology
MH  - Humans
MH  - Neuronal Plasticity/*physiology
OTO - NOTNLM
OT  - activite physique
OT  - acute exercise
OT  - brain plasticity
OT  - cellules endotheliales vasculaires
OT  - exercice ponctuel
OT  - physical activity
OT  - plaquettes
OT  - plasticite cerebrale
OT  - platelets
OT  - vascular endothelial cells
EDAT- 2018/05/19 06:00
MHDA- 2019/03/21 06:00
CRDT- 2018/05/19 06:00
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/05/19 06:00 [entrez]
AID - 10.1139/apnm-2018-0192 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 Nov;43(11):1095-1104. doi: 10.1139/apnm-2018-0192. 
      Epub 2018 May 18.