PMID- 29775669
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20231012
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Print)
IS  - 1359-6446 (Linking)
VI  - 23
IP  - 7
DP  - 2018 Jul
TI  - Nanogels as potential drug nanocarriers for CNS drug delivery.
PG  - 1436-1443
LID - S1359-6446(17)30576-7 [pii]
LID - 10.1016/j.drudis.2018.05.018 [doi]
AB  - Hydrogel-based drug delivery systems (DDSs) have versatile applications such, as 
      tissue engineering, scaffolds, drug delivery, and regenerative medicines. The 
      drawback of higher size and poor stability in such DDSs are being addressed by 
      developing nano-sized hydrogel particles, known as nanogels, to achieve the 
      desired biocompatibility and encapsulation efficiency for better efficacy than 
      conventional bulk hydrogels. In this review, we describe advances in the 
      development of nanogels and their promotion as nanocarriers to deliver 
      therapeutic agents to the central nervous system (CNS). We also discuss the 
      challenges, possible solutions, and future prospects for the use of nanogel-based 
      DDSs for CNS therapies.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Vashist, Arti
AU  - Vashist A
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA. Electronic address: avashist@fiu.edu.
FAU - Kaushik, Ajeet
AU  - Kaushik A
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA.
FAU - Vashist, Atul
AU  - Vashist A
AD  - Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 
      110029, India.
FAU - Bala, Jyoti
AU  - Bala J
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA.
FAU - Nikkhah-Moshaie, Roozbeh
AU  - Nikkhah-Moshaie R
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA.
FAU - Sagar, Vidya
AU  - Sagar V
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA.
FAU - Nair, Madhavan
AU  - Nair M
AD  - Centre for Personalized Nanomedicine, Institute of Neuro-Immune Pharmacology, 
      Department of Immunology, Herbert Wertheim College of Medicine, Florida 
      International University, Miami, FL, USA. Electronic address: nairm@fiu.edu.
LA  - eng
GR  - R01 DA042706/DA/NIDA NIH HHS/United States
GR  - R01 DA037838/DA/NIDA NIH HHS/United States
GR  - R01 DA040537/DA/NIDA NIH HHS/United States
GR  - R01 DA027049/DA/NIDA NIH HHS/United States
GR  - R01 DA034547/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20180520
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Gels)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/metabolism
MH  - Capillary Permeability
MH  - Central Nervous System Agents/*administration & dosage/chemistry/metabolism
MH  - *Drug Carriers
MH  - Drug Compounding
MH  - Gels
MH  - Humans
MH  - Nanomedicine/*methods
MH  - *Nanoparticles
PMC - PMC6598698
MID - NIHMS971493
EDAT- 2018/05/19 06:00
MHDA- 2018/11/27 06:00
PMCR- 2019/07/01
CRDT- 2018/05/19 06:00
PHST- 2017/12/11 00:00 [received]
PHST- 2018/03/20 00:00 [revised]
PHST- 2018/05/10 00:00 [accepted]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/05/19 06:00 [entrez]
PHST- 2019/07/01 00:00 [pmc-release]
AID - S1359-6446(17)30576-7 [pii]
AID - 10.1016/j.drudis.2018.05.018 [doi]
PST - ppublish
SO  - Drug Discov Today. 2018 Jul;23(7):1436-1443. doi: 10.1016/j.drudis.2018.05.018. 
      Epub 2018 May 20.