PMID- 29775753
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20190705
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 671
DP  - 2018 Sep 10
TI  - Long non-coding RNA biomarker for human laryngeal squamous cell carcinoma 
      prognosis.
PG  - 96-102
LID - S0378-1119(18)30535-3 [pii]
LID - 10.1016/j.gene.2018.05.046 [doi]
AB  - Long non-coding RNAs (lncRNA) were discovered in tumors. The regulation of lncRNA 
      in human laryngeal squamous cell carcinoma (LSCC) remains incomplete. Uncovering 
      the potential of lncRNA to stratify the prognosis of LSCC and streamline the vast 
      amount of clinical information will affect medical interventions. The surgical 
      resected LSCC tissues, adjacent non-cancerous tissues (ANCT) and lymph node 
      metastatic tissue (LNM) were collected from 76 patients for lncRNA AC008440.10 
      expression assay. The stages of LSCC and LNM were classified accordingly. We 
      integrated the epigenetic information with enhanced CT imaging and pathological 
      evaluations to predict the patients' survival by comprehensive statistical 
      algorithms using equal weighting. Significant downregulation of lncRNA 
      AC008440.10 was detected in LSCC tumor and metastatic lymph node in advanced 
      stage of patient samples compared with those in early stage. The pattern of 
      differentially expressed AC008440.10 displayed a clear trend that significantly 
      related to tumor progression. The downregulation of lncRNA AC008440.10 correlates 
      with increasing risk of metastasis, poor prognosis and patient survival. The 
      potential for lncRNA AC008440.10 to be developed as a novel biomarker for 
      stratification of the prognosis was especially promising when clinic parameters 
      were hybridized with equal weight, and using a panel of complementary parameters 
      yielded a more powerful predictability of LSCC prognosis than any single 
      parameter individually.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Chen, Jingjing
AU  - Chen J
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo City Medical 
      Treatment Center Lihuili Hospital, Ningbo 315000, Zhejiang, China.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo City Medical 
      Treatment Center Lihuili Hospital, Ningbo 315000, Zhejiang, China.
FAU - Deng, Hongxia
AU  - Deng H
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo City Medical 
      Treatment Center Lihuili Hospital, Ningbo 315000, Zhejiang, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Departmcnt of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, China, 310016.
FAU - Liao, Qi
AU  - Liao Q
AD  - Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of 
      Pathological and Physiological Technology, Medical School of Ningbo University, 
      Ningbo 315211, Zhejiang, China.
FAU - Mu, Ying
AU  - Mu Y
AD  - EagleImmune, Inc., 11361 Bishops Gate Ln, Laurel, MD 20723, USA. Electronic 
      address: yingm6@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180605
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Squamous Cell/genetics/*surgery
MH  - *Down-Regulation
MH  - Epigenesis, Genetic
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - Survival Analysis
OTO - NOTNLM
OT  - Biomarker
OT  - Laryngeal squamous cell carcinoma
OT  - Lymph node metastasis
OT  - Prognosi
OT  - lncRNA AC008440.10
EDAT- 2018/05/19 06:00
MHDA- 2019/07/06 06:00
CRDT- 2018/05/19 06:00
PHST- 2018/03/22 00:00 [received]
PHST- 2018/05/13 00:00 [accepted]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
PHST- 2018/05/19 06:00 [entrez]
AID - S0378-1119(18)30535-3 [pii]
AID - 10.1016/j.gene.2018.05.046 [doi]
PST - ppublish
SO  - Gene. 2018 Sep 10;671:96-102. doi: 10.1016/j.gene.2018.05.046. Epub 2018 Jun 5.