PMID- 29775944
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20181004
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 240
DP  - 2018 Sep
TI  - Alterations of cytochrome P450 and the occurrence of persistent organic 
      pollutants in tilapia caged in the reservoirs of the Iguacu River.
PG  - 670-682
LID - S0269-7491(17)31983-8 [pii]
LID - 10.1016/j.envpol.2018.04.019 [doi]
AB  - Environmental chemicals originating from human activities, such as persistent 
      organic pollutants (POPs), may interfere with the endocrine system of aquatic 
      organisms. The effect of these chemicals on biota and human populations is of 
      high public concern but remains poorly understood, especially in aquatic 
      environments of South America. The aim of this study was to investigate the 
      bioavailability of POPs and the related effects in caged male tilapia 
      (Oreochromis niloticus) in four cascading reservoirs of the Iguacu River, 
      Southern Brazil. POPs including organochlorine pesticides (OCPs), polychlorinated 
      biphenyl (PCBs), and polybrominated diphenyl ethers (PBDEs) were determined in 
      the reservoir water and tissue samples of tilapia after two months of exposure. 
      The PCB levels in water (14.7 ng L(-1)) were 14 times higher than the limits 
      permitted by the Brazilian legislation in the Salto Santiago (SS) reservoir. 
      Similarly, concentrations of aldrin and its metabolites (6.05 ng L(-1)) detected 
      in the water sample of the Salto Osorio (SO) reservoir were also above the 
      permitted limits. RT-qPCR analysis revealed different transcript levels of 
      cytochrome P450 enzymes (CYP1A and CYP3A) in the liver among the four groups, 
      with induced activity in tilapia from the SS reservoir. Quantification of the 
      CYP3A mRNA expression and catalytic activity showed higher values for fish caged 
      at the SS reservoir. The fish from this site also had a higher number of 
      eosinophils observed in the testes. Although overt measurements of endocrine 
      disruption were not observed in caged fish, alteration of CYP enzymes with 
      co-occurrence of organochlorine contaminants in water may suggest bioavailability 
      of contaminants from agricultural sources to biota. Additional studies with feral 
      or caged animals for a longer duration may be necessary to evaluate the risks of 
      the waterways to humans and wildlife.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Yamamoto, F Y
AU  - Yamamoto FY
AD  - Cell Biology Department, Federal University of Parana, Curitiba, Brazil. 
      Electronic address: fyamamoto@utfpr.edu.br.
FAU - Diamante, G D
AU  - Diamante GD
AD  - Department of Environmental Sciences, University of California Riverside, 
      Riverside, United States.
FAU - Santana, M S
AU  - Santana MS
AD  - Cell Biology Department, Federal University of Parana, Curitiba, Brazil.
FAU - Santos, D R
AU  - Santos DR
AD  - Cell Biology Department, Federal University of Parana, Curitiba, Brazil.
FAU - Bombardeli, R
AU  - Bombardeli R
AD  - Research Center in Environmental Aquaculture, Western University of Parana, 
      Toledo, Brazil.
FAU - Martins, C C
AU  - Martins CC
AD  - Center for Marine Studies, Federal University of Parana, Pontal do Parana, 
      Brazil.
FAU - Oliveira Ribeiro, C A
AU  - Oliveira Ribeiro CA
AD  - Cell Biology Department, Federal University of Parana, Curitiba, Brazil. 
      Electronic address: ciro@ufpr.br.
FAU - Schlenk, D
AU  - Schlenk D
AD  - Department of Environmental Sciences, University of California Riverside, 
      Riverside, United States.
LA  - eng
PT  - Journal Article
DEP - 20180516
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP3A)
SB  - IM
MH  - Animals
MH  - Biological Availability
MH  - Brazil
MH  - Cytochrome P-450 CYP1A1/*metabolism
MH  - Cytochrome P-450 CYP3A/*metabolism
MH  - Endocrine Disruptors/analysis/*pharmacokinetics
MH  - Fishes
MH  - Halogenated Diphenyl Ethers/analysis/pharmacokinetics
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/pharmacokinetics
MH  - Liver/*metabolism
MH  - Male
MH  - Pesticides/analysis/*pharmacokinetics
MH  - Polychlorinated Biphenyls/analysis/pharmacokinetics
MH  - Rivers/chemistry
MH  - Tilapia/*metabolism
MH  - Water Pollutants, Chemical/analysis/*pharmacokinetics
OTO - NOTNLM
OT  - CYP3A
OT  - Endocrine system
OT  - Iguacu River
OT  - Oreochromis niloticus
OT  - Persistent organic pollutants
EDAT- 2018/05/19 06:00
MHDA- 2018/09/19 06:00
CRDT- 2018/05/19 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2018/03/29 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/05/19 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/05/19 06:00 [entrez]
AID - S0269-7491(17)31983-8 [pii]
AID - 10.1016/j.envpol.2018.04.019 [doi]
PST - ppublish
SO  - Environ Pollut. 2018 Sep;240:670-682. doi: 10.1016/j.envpol.2018.04.019. Epub 
      2018 May 16.