PMID- 29778070
OWN - NLM
STAT- MEDLINE
DCOM- 20191101
LR  - 20200306
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 70
DP  - 2018 Aug
TI  - High-intensity binge drinking is associated with alterations in spontaneous 
      neural oscillations in young adults.
PG  - 51-60
LID - S0741-8329(17)30868-6 [pii]
LID - 10.1016/j.alcohol.2018.01.002 [doi]
AB  - Heavy episodic alcohol consumption (also termed binge drinking) contributes to a 
      wide range of health and cognitive deficits, but the associated brain-based 
      indices are poorly understood. The current study used electroencephalography 
      (EEG) to examine spontaneous neural oscillations in young adults as a function of 
      quantity, frequency, and the pattern of their alcohol consumption. Sixty-one 
      young adults (23.4 +/- 3.4 years of age) were assigned to binge drinking (BD) and 
      light drinking (LD) groups that were equated on gender, race/ethnic identity, 
      age, educational background, and family history of alcoholism. EEG activity was 
      recorded during eyes-open and eyes-closed resting conditions. Each participant's 
      alpha peak frequency (APF) was used to calculate absolute power in individualized 
      theta and alpha frequency bands, with a canonical frequency range used for beta. 
      APF was slower by 0.7 Hz in BD, especially in individuals engaging in 
      high-intensity drinking, but there were no changes in alpha power. BD also 
      exhibited higher frontal theta and beta power than LD. Alpha slowing and 
      increased theta power in BD remained after accounting for depression, anxiety, 
      and personality characteristics, while elevated beta power covaried with 
      sensation seeking. Furthermore, APF slowing and theta power correlated with 
      various measures of alcohol consumption, including binge episodes and blackouts, 
      but not with measures of working and episodic memory, cognitive flexibility, 
      processing speed, or personality variables, suggesting that these physiological 
      changes may be modulated by high-intensity alcohol intake. These results are 
      consistent with studies of alcohol-use disorder (AUD) and support the hypothesis 
      that binge drinking is a transitional stage toward alcohol dependence. The 
      observed thalamocortical dysrhythmia may be indicative of an 
      excitatory-inhibitory imbalance in BD and may potentially serve as an index of 
      the progressive development of AUD, with a goal of informing possible 
      interventions to minimize alcohol's deleterious effects on the brain.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Affan, Rifqi O
AU  - Affan RO
AD  - Department of Psychology, College of Sciences, San Diego State University, San 
      Diego, CA 92182-4611, United States.
FAU - Huang, Siyuan
AU  - Huang S
AD  - Department of Psychology, College of Sciences, San Diego State University, San 
      Diego, CA 92182-4611, United States.
FAU - Cruz, Stephen M
AU  - Cruz SM
AD  - Biology Department, College of Sciences, San Diego State University, San Diego, 
      CA 92182-4611, United States.
FAU - Holcomb, Lee A
AU  - Holcomb LA
AD  - Department of Psychology, College of Sciences, San Diego State University, San 
      Diego, CA 92182-4611, United States.
FAU - Nguyen, Edward
AU  - Nguyen E
AD  - Department of Psychology, College of Sciences, San Diego State University, San 
      Diego, CA 92182-4611, United States.
FAU - Marinkovic, Ksenija
AU  - Marinkovic K
AD  - Department of Psychology, College of Sciences, San Diego State University, San 
      Diego, CA 92182-4611, United States; Department of Radiology, School of Medicine, 
      University of California, San Diego, CA 92093-0841, United States. Electronic 
      address: kmarinkovic@sdsu.edu.
LA  - eng
GR  - R01 AA016624/AA/NIAAA NIH HHS/United States
GR  - T34 GM008303/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180108
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
SB  - IM
MH  - Binge Drinking/*physiopathology/psychology
MH  - Brain/*physiopathology
MH  - Brain Waves/*physiology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Young Adult
PMC - PMC5995627
MID - NIHMS932353
OTO - NOTNLM
OT  - Alcohol
OT  - Alpha
OT  - Alpha peak frequency
OT  - Beta
OT  - Resting-state EEG
OT  - Theta
COIS- Conflicts of interest None of the authors have potential conflicts of interest to 
      be disclosed.
EDAT- 2018/05/20 06:00
MHDA- 2019/11/02 06:00
PMCR- 2019/08/01
CRDT- 2018/05/20 06:00
PHST- 2017/08/28 00:00 [received]
PHST- 2018/01/04 00:00 [revised]
PHST- 2018/01/04 00:00 [accepted]
PHST- 2018/05/20 06:00 [pubmed]
PHST- 2019/11/02 06:00 [medline]
PHST- 2018/05/20 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - S0741-8329(17)30868-6 [pii]
AID - 10.1016/j.alcohol.2018.01.002 [doi]
PST - ppublish
SO  - Alcohol. 2018 Aug;70:51-60. doi: 10.1016/j.alcohol.2018.01.002. Epub 2018 Jan 8.