PMID- 29778549 OWN - NLM STAT- MEDLINE DCOM- 20190715 LR - 20190715 IS - 1728-7731 (Electronic) IS - 1726-4901 (Linking) VI - 81 IP - 12 DP - 2018 Dec TI - Linked color imaging can help gastric Helicobacter pylori infection diagnosis during endoscopy. PG - 1033-1037 LID - S1726-4901(18)30096-0 [pii] LID - 10.1016/j.jcma.2018.03.006 [doi] AB - BACKGROUND: Esophagogastroduodenoscopy (EGD) is a standard tool for detection of mucosal and submucosal lesions. However, identification of Helicobacter pylori (H. P) infection using EGD alone is limited in accuracy. Linked color imaging (LCI) is a novel tool to capture real-time image with sufficient contrast to observe mucosal microstructure. METHODS: This study aims to evaluate the applicability of LCI in the identification of H. pylori infection. Consecutive 122 patients scheduled for EGD were included. They were examined with LCI and magnifying endoscopy. The classification of H. pylori was based on pathology results of biopsy and rapid urease test or urea breath test. RESULTS: We compared the results based on LCI or magnifying endoscopy to reference classification. Of 122 patients, 36 had H. pylori infection (29.51%). The level of accuracy of diagnosis of H. pylori infections by LCI, magnifying endoscopy, and both LCI and magnifying endoscopy was 78.38%, 81.98%, and 78.38%, respectively. The sensitivity and specificity of each group were 70.97%, 81.25%, and 80.65% and 82.5%, 83.87%, and 76.25%, respectively. The positive predictive values were 59.46%, 64.10%, and 57.78%, respectively, and the negative predictive values were 87.84%, 91.67%, and 92.42%, respectively. CONCLUSION: LCI could be playing a valuable initial screen tool for real-time diagnosis of H. pylori infections. It has a high accuracy of diagnosis of H. pylori infections. Therefore, in patients suspected to have H. pylori infections using LCI, the infections need to be carefully diagnosed using appropriate methods because, as per the consensus, they should be eradicated as soon as possible before precancerous lesions develop. CI - Copyright (c) 2018. Published by Elsevier Taiwan LLC. FAU - Chen, Tsung-Hsing AU - Chen TH AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan, ROC. FAU - Hsu, Chen-Ming AU - Hsu CM AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Cheng, Hao-Tsai AU - Cheng HT AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Chu, Yin-Yi AU - Chu YY AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Su, Ming-Yao AU - Su MY AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Hsu, Jun-Te AU - Hsu JT AD - Department of Surgery, Chang Gung Memorial Hospital-Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Yeh, Ta-Sen AU - Yeh TS AD - Department of Surgery, Chang Gung Memorial Hospital-Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Kuo, Chang-Fu AU - Kuo CF AD - Division of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. FAU - Chiu, Cheng-Tang AU - Chiu CT AD - Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital- Linkou and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. Electronic address: ctchiu@adm.cgmh.org.tw. LA - eng PT - Journal Article DEP - 20180531 PL - Netherlands TA - J Chin Med Assoc JT - Journal of the Chinese Medical Association : JCMA JID - 101174817 SB - IM MH - Adult MH - Aged MH - Endoscopy, Gastrointestinal MH - Female MH - Gastric Mucosa/*diagnostic imaging MH - Helicobacter Infections/*diagnosis MH - *Helicobacter pylori MH - Humans MH - Male MH - Middle Aged OTO - NOTNLM OT - H. pylori infection OT - Image-enhanced endoscopy OT - Linked color imaging OT - White light imaging EDAT- 2018/05/21 06:00 MHDA- 2019/07/16 06:00 CRDT- 2018/05/21 06:00 PHST- 2017/06/01 00:00 [received] PHST- 2018/02/12 00:00 [revised] PHST- 2018/03/19 00:00 [accepted] PHST- 2018/05/21 06:00 [pubmed] PHST- 2019/07/16 06:00 [medline] PHST- 2018/05/21 06:00 [entrez] AID - S1726-4901(18)30096-0 [pii] AID - 10.1016/j.jcma.2018.03.006 [doi] PST - ppublish SO - J Chin Med Assoc. 2018 Dec;81(12):1033-1037. doi: 10.1016/j.jcma.2018.03.006. Epub 2018 May 31.