PMID- 29778668
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 12
IP  - 6
DP  - 2018 Nov
TI  - Thinking about brain insulin resistance.
PG  - 1091-1094
LID - S1871-4021(18)30162-0 [pii]
LID - 10.1016/j.dsx.2018.05.003 [doi]
AB  - INTRODUCTION: Dementia and type 2 diabetes mellitus (T2DM) are two of the 
      epidemics of our time; in which insulin resistance (IR) is playing the central 
      role. Epidemiological studies found that different types of dementia development 
      may be promoted by the presence of T2DM. OBJECTIVES: We aimed in this review to 
      highlight the role of insulin and the IR in the brain as a pathophysiological 
      factor of dementia development and also to expand our understanding of T2DM as a 
      mediator of IR in the brain and to review the possible mechanisms of action that 
      may explain the association. METHODOLOGY: A critical review of the relevant 
      published English articles up to 2018, using PubMed, Google Scholar, Science 
      Direct, ADI, and WHO database was carried out. Keywords were included insulin 
      resistance, T3DM, T2DM, dementia, brain insulin resistance were used. CONCLUSION: 
      The rapidly increased prevalence of dementia concurrently with T2DM and obesity 
      need urgent action to illustrate guidelines for prevention, modifying, and 
      treatment based on mechanistic studies.
CI  - Copyright (c) 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Al Haj Ahmad, Reem M
AU  - Al Haj Ahmad RM
AD  - Department of Nutrition and Food Technology, Faculty of Agriculture, The 
      University of Jordan, Queen Rania Street, Amman 11942, Jordan.
FAU - Al-Domi, Hayder A
AU  - Al-Domi HA
AD  - Department of Nutrition and Food Technology, Faculty of Agriculture, The 
      University of Jordan, Queen Rania Street, Amman 11942, Jordan. Electronic 
      address: h.aldomi@ju.edu.jo.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180506
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Dementia/*etiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - Insulin/*metabolism
MH  - *Insulin Resistance
OTO - NOTNLM
OT  - Blood brain barrier (BBB)
OT  - Neurons
OT  - Type 2 diabetes mellitus (T2DM)
OT  - Type 3 diabetes mellitus (T3DM)
EDAT- 2018/05/21 06:00
MHDA- 2019/01/08 06:00
CRDT- 2018/05/21 06:00
PHST- 2018/04/24 00:00 [received]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/05/21 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/05/21 06:00 [entrez]
AID - S1871-4021(18)30162-0 [pii]
AID - 10.1016/j.dsx.2018.05.003 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2018 Nov;12(6):1091-1094. doi: 10.1016/j.dsx.2018.05.003. 
      Epub 2018 May 6.