PMID- 29778891
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20190111
IS  - 1549-9642 (Electronic)
IS  - 1549-9634 (Linking)
VI  - 14
IP  - 6
DP  - 2018 Aug
TI  - Leukocytes and drug-resistant cancer cells are targets for intracellular delivery 
      by adenoviral dodecahedron.
PG  - 1853-1865
LID - S1549-9634(18)30092-3 [pii]
LID - 10.1016/j.nano.2018.05.001 [doi]
AB  - One of the major factors limiting the effectiveness of cancer chemotherapy is 
      inefficient drug delivery. Systems enabling efficient delivery and enhanced 
      intracellular uptake appear particularly promising in this respect. Virus-like 
      particle, adenoviral dodecahedron (Dd), employs receptor-mediated endocytosis for 
      cell penetration and is able to deliver intracellularly dozens of cargo molecules 
      attached to one particle. We focused on studying Dd properties in the context of 
      cancer treatment, showing that intratumoral injection of Dd, assessed in mouse 
      xenograft model, results in vector accumulation in tumor without spreading in 
      off-target organs. Moreover, we demonstrated that Dd is a promising vector 
      targeting leukocytes and drug-resistant cancer cells. Dd uptake by human blood 
      cells analyzed in vitro indicated the preference for leukocytes in comparison to 
      red blood cells and platelets. Furthermore, internalization of Dd-doxorubicin 
      conjugate by drug-resistant cells leads to increased nuclear accumulation of 
      doxorubicin and significant enhancement of cytotoxicity against target cancer 
      cells.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Jedynak, Marta
AU  - Jedynak M
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland.
FAU - Laurin, David
AU  - Laurin D
AD  - Universite Grenoble Alpes, Etablissement Francais du Sang, IAB, Inserm U1209 & 
      CNRS UMR5309, Grenoble, France.
FAU - Dolega, Patryk
AU  - Dolega P
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland.
FAU - Podsiadla-Bialoskorska, Malgorzata
AU  - Podsiadla-Bialoskorska M
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland.
FAU - Szurgot, Inga
AU  - Szurgot I
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland.
FAU - Chroboczek, Jadwiga
AU  - Chroboczek J
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland; Universite Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, 
      France.
FAU - Szolajska, Ewa
AU  - Szolajska E
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland. Electronic address: ewasz@ibb.waw.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180517
PL  - United States
TA  - Nanomedicine
JT  - Nanomedicine : nanotechnology, biology, and medicine
JID - 101233142
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Capsid Proteins)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Adenoviridae/*genetics
MH  - Animals
MH  - Antibiotics, Antineoplastic/pharmacology
MH  - Capsid Proteins/*administration & dosage/genetics
MH  - Cells, Cultured
MH  - Doxorubicin/*pharmacology
MH  - *Drug Delivery Systems
MH  - *Drug Resistance, Neoplasm
MH  - Humans
MH  - Leukocytes/cytology/*metabolism
MH  - Mice
MH  - Neoplasms/*therapy
OTO - NOTNLM
OT  - Adenoviral dodecahedron
OT  - Drug delivery, drug resistance, in vivo imaging
OT  - Virus-like particle
EDAT- 2018/05/21 06:00
MHDA- 2019/01/12 06:00
CRDT- 2018/05/21 06:00
PHST- 2017/11/15 00:00 [received]
PHST- 2018/04/04 00:00 [revised]
PHST- 2018/05/04 00:00 [accepted]
PHST- 2018/05/21 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2018/05/21 06:00 [entrez]
AID - S1549-9634(18)30092-3 [pii]
AID - 10.1016/j.nano.2018.05.001 [doi]
PST - ppublish
SO  - Nanomedicine. 2018 Aug;14(6):1853-1865. doi: 10.1016/j.nano.2018.05.001. Epub 
      2018 May 17.