PMID- 29779037
OWN - NLM
STAT- MEDLINE
DCOM- 20181017
LR  - 20201209
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 275
IP  - 7
DP  - 2018 Jul
TI  - Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic 
      cheilitis and lip cancer.
PG  - 1877-1883
LID - 10.1007/s00405-018-5002-8 [doi]
AB  - PURPOSE: The aim of this work was to evaluate the expression of the cancer stem 
      cell (CSC) markers CD44, ALDH1 and p75NTR in the ultraviolet-induced lesions 
      actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC), and to correlate 
      it with p53 expression. METHODS: Immunohistochemistry was performed in 4 cases of 
      normal lip (NL), 43 of AC and 20 of LSCC. RESULTS: All cases were positive for 
      CD44, showing a membranous staining without differences between the groups. ALDH1 
      showed cytoplasmic staining and it was invariable amongst the grades of 
      epithelial dysplasia and between AC and LSCC. p75NTR presented 
      membranous/cytoplasmic staining in the basal and parabasal layer of NL and AC, 
      while LSCC presented cytoplasmic staining in the peripheral layers of the tumor 
      islands. p75NTR showed different expression amongst the dysplasia grades 
      (p < 0.001) but no differences between AC and LSCC. p53 expression was similar 
      amongst the dysplasia grades and between AC and LSCC. CD44, ALDH1 and p75NTR were 
      unrelated amongst themselves and to p53 expression. CONCLUSIONS: CSC markers are 
      expressed in potentially malignant and malignant lesions of the lip. Their 
      expressions were invariable between AC and LSCC and unrelated to p53. p75NTR 
      expression increased with the worsening of epithelial dysplasia grade.
FAU - Custodio, Marcos
AU  - Custodio M
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo, Av. Prof. Lineu Prestes, 2227, Sao Paulo, SP, 05508-000, Brazil.
FAU - Pelissari, Cibele
AU  - Pelissari C
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo, Av. Prof. Lineu Prestes, 2227, Sao Paulo, SP, 05508-000, Brazil.
FAU - Santana, Thalita
AU  - Santana T
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo, Av. Prof. Lineu Prestes, 2227, Sao Paulo, SP, 05508-000, Brazil.
FAU - Trierveiler, Marilia
AU  - Trierveiler M
AUID- ORCID: 0000-0002-8517-2105
AD  - Department of Oral and Maxillofacial Pathology, School of Dentistry, University 
      of Sao Paulo, Av. Prof. Lineu Prestes, 2227, Sao Paulo, SP, 05508-000, Brazil. 
      trierveiler@usp.br.
LA  - eng
GR  - 08/54606-9/Fapesp/
PT  - Journal Article
DEP - 20180519
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Biomarkers)
RN  - 0 (CD44 protein, human)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Isoenzymes)
RN  - 0 (NGFR protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 1.2.1 (Aldehyde Dehydrogenase 1 Family)
RN  - EC 1.2.1.36 (ALDH1A1 protein, human)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
RN  - Actinic cheilitis
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aldehyde Dehydrogenase 1 Family
MH  - Biomarkers/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Cheilitis/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Hyaluronan Receptors/*metabolism
MH  - Immunohistochemistry
MH  - Isoenzymes/*metabolism
MH  - Lip Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplastic Stem Cells
MH  - Nerve Tissue Proteins/*metabolism
MH  - Receptors, Nerve Growth Factor/*metabolism
MH  - Retinal Dehydrogenase/*metabolism
OTO - NOTNLM
OT  - Actinic cheilitis
OT  - Cancer stem cells
OT  - Head and neck neoplasms
OT  - Lip neoplasms
OT  - Ultraviolet radiation
EDAT- 2018/05/21 06:00
MHDA- 2018/10/18 06:00
CRDT- 2018/05/21 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/05/14 00:00 [accepted]
PHST- 2018/05/21 06:00 [pubmed]
PHST- 2018/10/18 06:00 [medline]
PHST- 2018/05/21 06:00 [entrez]
AID - 10.1007/s00405-018-5002-8 [pii]
AID - 10.1007/s00405-018-5002-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2018 Jul;275(7):1877-1883. doi: 
      10.1007/s00405-018-5002-8. Epub 2018 May 19.