PMID- 29780293
OWN - NLM
STAT- MEDLINE
DCOM- 20180927
LR  - 20220321
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 33
IP  - 21
DP  - 2018 May 21
TI  - Serial Changes of Cytokines in Children with Cerebral Palsy Who Received 
      Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous 
      Mobilized Peripheral Blood Mononuclear Cells.
PG  - e102
LID - 10.3346/jkms.2018.33.e102 [doi]
LID - e102
AB  - BACKGROUND: This study was performed to assess serial cytokine changes and their 
      clinical impact in children with cerebral palsy (CP) who received 
      granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous 
      mobilized peripheral blood mononuclear cells (mPBMCs). METHODS: Peripheral blood 
      (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 
      months after G-CSF infusion as well as at the end of the study. Cytokine levels 
      were measured by enzyme-linked immunosorbent assays with plasma samples. RESULTS: 
      There were no significant differences in cytokine levels between the mPBMC and 
      placebo groups over 6 months. However, when clinical responders and 
      non-responders were compared, interleukin (IL)-6 (P = 0.050) as well as G-CSF (P 
      = 0.010) were higher in the responders than the non-responders at 1 month, while 
      brain-derived neurotrophic factor (BDNF) (P = 0.030) and insulin-like growth 
      factor (IGF)-1 (P = 0.001) were lower. In addition, BDNF was higher at baseline 
      in the responders than the non-responders (P = 0.030). CONCLUSION: The changes of 
      G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated 
      with the clinical improvement of neurologic functions. The G-CSF-induced changes 
      of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as 
      prognostic factors in G-CSF trials in CP children.
FAU - Koh, Hani
AU  - Koh H
AUID- ORCID: 0000-0002-2351-6443
AD  - Department of Translational Medicine, Graduate School of Biomedical Science & 
      Engineering, Hanyang University, Seoul, Korea.
AD  - Blood and Marrow Transplantation Center, Hanyang University Medical Center, 
      Seoul, Korea.
FAU - Rah, Wee-Jin
AU  - Rah WJ
AUID- ORCID: 0000-0001-6634-1420
AD  - Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea.
FAU - Kim, Yong-Joo
AU  - Kim YJ
AUID- ORCID: 0000-0002-2654-5397
AD  - Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea.
FAU - Moon, Jin-Hwa
AU  - Moon JH
AUID- ORCID: 0000-0003-0235-5318
AD  - Department of Pediatrics, Hanyang University Medical Center, Guri Hospital, Guri, 
      Korea.
FAU - Kim, Mi-Jung
AU  - Kim MJ
AUID- ORCID: 0000-0003-2920-9900
AD  - Department of Rehabilitation Medicine, Hanyang University Medical Center, Seoul, 
      Korea.
FAU - Lee, Young-Ho
AU  - Lee YH
AUID- ORCID: 0000-0003-1498-2773
AD  - Department of Translational Medicine, Graduate School of Biomedical Science & 
      Engineering, Hanyang University, Seoul, Korea.
AD  - Blood and Marrow Transplantation Center, Hanyang University Medical Center, 
      Seoul, Korea.
AD  - Department of Pediatrics, Hanyang University Medical Center, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180306
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
CIN - J Korean Med Sci. 2018 May 16;33(21):e176. PMID: 29780298
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cerebral Palsy/*drug therapy/therapy
MH  - Child
MH  - Cytokines/*blood
MH  - Double-Blind Method
MH  - Granulocyte Colony-Stimulating Factor/*therapeutic use
MH  - Humans
MH  - Insulin-Like Growth Factor I/analysis
MH  - Interleukin-6/analysis
MH  - Leukocytes, Mononuclear/cytology/metabolism/*transplantation
MH  - Placebo Effect
MH  - Transplantation, Autologous
MH  - Treatment Outcome
PMC - PMC5955735
OTO - NOTNLM
OT  - Cerebral Palsy
OT  - Cytokines
OT  - Granulocyte-colony Stimulating Factor (G-CSF)
OT  - Peripheral Blood Mononuclear Cells
COIS- Disclosure: The authors have no potential conflicts of interest to disclose.
EDAT- 2018/05/22 06:00
MHDA- 2018/09/28 06:00
PMCR- 2018/05/21
CRDT- 2018/05/22 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2017/12/15 00:00 [accepted]
PHST- 2018/05/22 06:00 [entrez]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2018/09/28 06:00 [medline]
PHST- 2018/05/21 00:00 [pmc-release]
AID - 10.3346/jkms.2018.33.e102 [doi]
PST - epublish
SO  - J Korean Med Sci. 2018 Mar 6;33(21):e102. doi: 10.3346/jkms.2018.33.e102. 
      eCollection 2018 May 21.