PMID- 29780640
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2018
DP  - 2018
TI  - Plasma Chemerin Levels Are Increased in ST Elevation Myocardial Infarction 
      Patients with High Thrombus Burden.
PG  - 5812704
LID - 10.1155/2018/5812704 [doi]
LID - 5812704
AB  - OBJECTIVE: To investigate plasma chemerin levels in ST elevation myocardial 
      infarction (STEMI) patients and find out possible relationships between plasma 
      chemerin levels and angiographic characteristics. PATIENTS AND METHODS: 
      Ninety-seven consecutive patients who presented with STEMI and underwent primary 
      percutaneous coronary intervention (PCI) with coronary stents were enrolled, and 
      30 age- and sex-matched patients with stable angina pectoris who underwent 
      coronary angiography formed the control group. Angiographic characteristics of 
      the patients including thrombolysis in myocardial infarction (TIMI) thrombus and 
      Gensini scores were noted. Blood samples were taken to detect several biochemical 
      markers including plasma chemerin levels at the admission to hospital. RESULTS: 
      Serum chemerin and C-reactive protein (CRP) levels were significantly increased 
      in patients with STEMI. Among STEMI patients, serum chemerin levels were 
      significantly higher in patients with high thrombus burden (581.5 +/- 173.7 versus 
      451.3 +/- 101.2 mg/dL, p < 0.001). CRP levels and peak creatine kinase-MB (CK-MB) 
      levels were higher, and left ventricular ejection fraction and post-PCI TIMI flow 
      were lower in patients with high thrombus burden. After multivariate analysis, 
      serum chemerin levels were also higher in patients with high thrombus grade (odds 
      ratio: 1.009 (1.005-1.014), p < 0.001). Besides, serum chemerin levels were also 
      found to be significantly correlated with CRP (r=0.47, p < 0.001) and peak CK-MB 
      (r=0.376, p < 0.001) levels. CONCLUSIONS: Results from our study have 
      demonstrated for the first time that chemerin levels were higher in STEMI 
      patients with greater thrombus burden and higher level of inflammation.
FAU - Ates, Ahmet Hakan
AU  - Ates AH
AD  - Department of Cardiology, Samsun Training and Research Hospital, University of 
      Health Sciences, Samsun, Turkey.
FAU - Arslan, Ugur
AU  - Arslan U
AUID- ORCID: 0000-0001-8572-3571
AD  - Department of Cardiology, Samsun Training and Research Hospital, University of 
      Health Sciences, Samsun, Turkey.
FAU - Aksakal, Aytekin
AU  - Aksakal A
AD  - Department of Cardiology, Samsun Training and Research Hospital, University of 
      Health Sciences, Samsun, Turkey.
FAU - Yanik, Ahmet
AU  - Yanik A
AD  - Department of Cardiology, Samsun Training and Research Hospital, University of 
      Health Sciences, Samsun, Turkey.
FAU - Ozdemir, Metin
AU  - Ozdemir M
AD  - Department of Microbiology, Gazi State Hospital, Samsun, Turkey.
FAU - Kul, Selim
AU  - Kul S
AD  - Department of Cardiology, Ahi Evren Training and Research Hospital, University of 
      Health Sciences, Trabzon, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180326
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC5892252
EDAT- 2018/05/22 06:00
MHDA- 2018/05/22 06:01
PMCR- 2018/03/26
CRDT- 2018/05/22 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/05/22 06:00 [entrez]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2018/05/22 06:01 [medline]
PHST- 2018/03/26 00:00 [pmc-release]
AID - 10.1155/2018/5812704 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2018 Mar 26;2018:5812704. doi: 10.1155/2018/5812704. 
      eCollection 2018.