PMID- 29781786
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181108
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 40
IP  - 9
DP  - 2018 Sep
TI  - Sitagliptin rescues memory deficits in Parkinsonian rats via upregulating BDNF to 
      prevent neuron and dendritic spine loss.
PG  - 736-743
LID - 10.1080/01616412.2018.1474840 [doi]
AB  - OBJECTIVES: Parkinson's disease (PD) is a neurodegenerative disease with high 
      morbidity among adults worldwide that causes tremendous trouble to people's 
      lives. The purpose of this study was to investigate the impact of sitagliptin on 
      PD and its potential mechanism. METHODS: First, the memory of rats in each group 
      was evaluated with the Morris water maze (MWM) test and the passive avoidance 
      test. Then, both brain-derived neurotrophic factor (BDNF) protein and mRNA levels 
      were detected by ELISA and qPCR assays, respectively. Then, rapid Golgi 
      impregnation was used to observe the density of dendritic spines in the 
      hippocampal CA1 area. Finally, k252a, an antagonist of Trk receptors, was used to 
      block the binding of BDNF with its receptors, and the effects of sitagliptin on 
      PD improvement were detected. RESULTS: Our study showed that sitagliptin improved 
      memory deficits in PD rats. Meanwhile, the expression level of BDNF and tyrosine 
      hydroxylase (TH) was upregulated, and the density of dendritic spine was 
      increased by sitagliptin administration. Moreover, K252a administration blocked 
      the positive effects of sitagliptin on memory in PD rats. DISCUSSION: Sitagliptin 
      rescued the memory deficits, which was achieved by upregulating BDNF to prevent 
      neuronal death and dendritic spine loss. Our findings indicate that sitagliptin 
      might be a promising potential drug for PD treatment in the future.
FAU - Li, Jing
AU  - Li J
AD  - a Department of Geriatrics , the Second Affiliated Hospital of Harbin Medical 
      University , Harbin , Heilongjiang P.R. China.
FAU - Zhang, Shuhu
AU  - Zhang S
AD  - a Department of Geriatrics , the Second Affiliated Hospital of Harbin Medical 
      University , Harbin , Heilongjiang P.R. China.
FAU - Li, Chenye
AU  - Li C
AD  - a Department of Geriatrics , the Second Affiliated Hospital of Harbin Medical 
      University , Harbin , Heilongjiang P.R. China.
FAU - Li, Mei
AU  - Li M
AD  - a Department of Geriatrics , the Second Affiliated Hospital of Harbin Medical 
      University , Harbin , Heilongjiang P.R. China.
FAU - Ma, Lan
AU  - Ma L
AD  - a Department of Geriatrics , the Second Affiliated Hospital of Harbin Medical 
      University , Harbin , Heilongjiang P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180521
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Nootropic Agents)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - TS63EW8X6F (Sitagliptin Phosphate)
SB  - IM
MH  - Animals
MH  - Antiparkinson Agents/pharmacology
MH  - Avoidance Learning/drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbazoles/pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Indole Alkaloids/pharmacology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Memory Disorders/*drug therapy/etiology/metabolism/pathology
MH  - Neurons/*drug effects/metabolism/pathology
MH  - Neuroprotective Agents/pharmacology
MH  - Nootropic Agents/*pharmacology
MH  - Parkinsonian Disorders/*drug therapy/metabolism/pathology/psychology
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Sitagliptin Phosphate/*pharmacology
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - Up-Regulation/drug effects
OTO - NOTNLM
OT  - BDNF
OT  - Morris Water Maze
OT  - Parkinson's disease
OT  - Sitagliptin
OT  - dendritic spine
OT  - passive avoidance
EDAT- 2018/05/22 06:00
MHDA- 2018/11/09 06:00
CRDT- 2018/05/22 06:00
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - 10.1080/01616412.2018.1474840 [doi]
PST - ppublish
SO  - Neurol Res. 2018 Sep;40(9):736-743. doi: 10.1080/01616412.2018.1474840. Epub 2018 
      May 21.