PMID- 29782643
OWN - NLM
STAT- MEDLINE
DCOM- 20190326
LR  - 20210109
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Print)
IS  - 0001-6349 (Linking)
VI  - 97
IP  - 10
DP  - 2018 Oct
TI  - Lifetime number of years of menstruation as a risk index for postmenopausal 
      endometrial cancer in the Norwegian Women and Cancer Study.
PG  - 1168-1177
LID - 10.1111/aogs.13381 [doi]
AB  - INTRODUCTION: Lifetime number of years of menstruation (LNYM) reflects a woman's 
      cumulative exposure to endogenous estrogen and can be used as a measure of the 
      combined effect of reproductive factors related to endometrial cancer (EC) risk. 
      MATERIAL AND METHODS: We aimed to study the association between LNYM and EC risk 
      among postmenopausal women and calculate the population attributable fraction of 
      EC for different LNYM categories. Our study sample consisted of 117 589 women 
      from the Norwegian Women and Cancer (NOWAC) Study. All women were aged 
      30-70 years at enrollment and completed a baseline questionnaire between 1991 and 
      2006. Women were followed up for EC to December 2014 through linkages to national 
      registries. We used Cox proportional hazards models to estimate hazard ratios 
      with 95% confidence intervals (95% CIs), adjusted for potential confounders. 
      RESULTS: In all, 720 women developed EC. We found a statistically significant, 
      positive dose-response relationship between LNYM and EC, with a 9.1% higher risk 
      for each additional year of LNYM (P for trend < .001). Using the LNYM category 
      >/=40 as a reference, the hazard ratios for LNYM <25, 25-29, 30-34, 35-39 were 0.17 
      (95% CI 0.22-0.27), 0.25 (95% CI 0.17-0.36), 0.43 (95% CI 0.32-0.58), and 0.68 
      (95% CI 0.51-0.92), respectively. The association between LNYM and EC was 
      independent of incomplete pregnancies, menopausal hormone therapy, diabetes, and 
      body mass index. When considering the population attributable fraction, 67% of EC 
      was estimated to be attributable to LNYM >/=25 years. CONCLUSIONS: Our study 
      supports that increasing LNYM is an important and independent predictor of EC 
      risk.
CI  - (c) 2018 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by 
      John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics 
      and Gynecology (NFOG).
FAU - Gavrilyuk, Oxana
AU  - Gavrilyuk O
AUID- ORCID: 0000-0003-3939-6420
AD  - Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic 
      University of Norway, Tromso, Norway.
FAU - Braaten, Tonje
AU  - Braaten T
AD  - Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic 
      University of Norway, Tromso, Norway.
FAU - Weiderpass, Elisabete
AU  - Weiderpass E
AUID- ORCID: 0000-0003-2237-0128
AD  - Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic 
      University of Norway, Tromso, Norway.
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden.
AD  - Department of Research, Cancer Registry of Norway, Institute of Population-Based 
      Cancer Research, Oslo, Norway.
AD  - Genetic Epidemiology Group, Folkhalsan Research Center, and Faculty of Medicine, 
      University of Helsinki, Helsinki, Finland.
FAU - Licaj, Idlir
AU  - Licaj I
AD  - Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic 
      University of Norway, Tromso, Norway.
FAU - Lund, Eiliv
AU  - Lund E
AD  - Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic 
      University of Norway, Tromso, Norway.
AD  - Department of Research, Cancer Registry of Norway, Institute of Population-Based 
      Cancer Research, Oslo, Norway.
LA  - eng
GR  - Northern Norway Regional Health Authority/
GR  - Faculty of Health Sciences/
GR  - UiT The Arctic University of Norway/
GR  - Norwegian Cancer Society/
PT  - Journal Article
DEP - 20180716
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endometrial Neoplasms/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - *Menstruation
MH  - Middle Aged
MH  - Norway
MH  - *Postmenopause
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Time Factors
MH  - Women's Health/*statistics & numerical data
PMC - PMC6175350
OTO - NOTNLM
OT  - endometrial cancer
OT  - menopause
OT  - number of menstruations
OT  - prospective study
OT  - reproductive factors
EDAT- 2018/05/22 06:00
MHDA- 2019/03/27 06:00
PMCR- 2018/10/08
CRDT- 2018/05/22 06:00
PHST- 2018/02/12 00:00 [received]
PHST- 2018/05/02 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
PHST- 2018/10/08 00:00 [pmc-release]
AID - AOGS13381 [pii]
AID - 10.1111/aogs.13381 [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2018 Oct;97(10):1168-1177. doi: 10.1111/aogs.13381. 
      Epub 2018 Jul 16.