PMID- 29782787
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20180709
IS  - 0010-6178 (Print)
IS  - 0010-6178 (Linking)
VI  - 80
IP  - 8
DP  - 2016 Sep
TI  - Propofol Induced Hyperkalemia and Its Management in End Stage Renal Disease 
      Patients.
PG  - 491-493
AB  - Propofol related infusion syndrome (PRIS) is a rare, but extremely dangerous 
      complication of propofol administration. Unexplained anion-gap metabolic 
      acidosis, rhabdomyolysis, hyperkalemia, acute kidney injury, elevated liver 
      enzymes, and potentially fatal cardiac arrhythmias are characteristic of PRIS. 
      Risk factors for the develop- ment of PRIS include dose and duration of propofol 
      infusion, severe illness, and concomitant administration of catecholamine and 
      glucocorticoids. PRIS causing hyperkalemia is a well-known clinical entity. 
      Although the development of PRIS depends on the duration and total amount of drug 
      infused, repeated boluses of propofol, commonly used for rapid sequence 
      intubation and conscious sedation, can potentially precipitate fatal 
      hyperkalemia. This is of particular concern in advanced chronic kidney disease 
      (CKD) and end stage renal disease (ESRD) patients. We report a case of a propofol 
      induced hyperkalemia causing near fatal cardiac arrhythmia in a dialysis 
      dependent ESRD patient. We report successful revival from cardiac arrest by 
      intensive calcium regimen and hemodialysis. This case highlights underrecognized 
      problem of propofol-induced hy- perkalemia, which can be of particular concerns 
      in advanced CKD and ESRD.
FAU - Virmani, Sarthak
AU  - Virmani S
FAU - Onuchic, Ana
AU  - Onuchic A
FAU - El-Ali, Ibrahim M
AU  - El-Ali IM
FAU - Trivedi, Ruchir D
AU  - Trivedi RD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Conn Med
JT  - Connecticut medicine
JID - 0372745
RN  - 0 (Anesthetics, Intravenous)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anesthetics, Intravenous/administration & dosage/adverse effects
MH  - *Arrhythmias, Cardiac/diagnosis/etiology/therapy
MH  - Electrocardiography/methods
MH  - Heart Arrest/etiology/therapy
MH  - Humans
MH  - *Hyperkalemia/chemically induced/diagnosis/physiopathology/therapy
MH  - *Kidney Failure, Chronic/blood/complications/physiopathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Patient Care Management/methods
MH  - Propofol/administration & dosage/*adverse effects
MH  - Renal Dialysis/*methods
MH  - Treatment Outcome
EDAT- 2016/09/01 00:00
MHDA- 2016/09/01 00:01
CRDT- 2018/05/22 06:00
PHST- 2018/05/22 06:00 [entrez]
PHST- 2016/09/01 00:00 [pubmed]
PHST- 2016/09/01 00:01 [medline]
PST - ppublish
SO  - Conn Med. 2016 Sep;80(8):491-493.