PMID- 29782918
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 90
DP  - 2018 May 18
TI  - BDNF haploinsufficiency exerts a transient and regionally different influence 
      upon oligodendroglial lineage cells during postnatal development.
PG  - 12-21
LID - S1044-7431(17)30375-5 [pii]
LID - 10.1016/j.mcn.2018.05.005 [doi]
AB  - Brain-Derived Neurotrophic Factor (BDNF) plays important roles in promoting 
      myelination in the developing central nervous system (CNS), however the influence 
      it exerts on oligodendrocyte development in vivo remains unclear. As BDNF 
      knockout mice die in the perinatal period, we undertook a systematic 
      developmental analysis of oligodendroglial lineage cells within multiple CNS 
      regions of BDNF heterozygous (HET) mice. Our data identify that BDNF 
      heterozygosity results in transient reductions in oligodendroglial lineage cell 
      density and progression that are largely restricted to the optic nerve, whereas 
      the corpus callosum, cerebral cortex, basal forebrain and spinal cord white 
      matter tracts are unaffected. In the first two postnatal weeks, BDNF HET mice 
      exhibit reductions in the density of oligodendroglial lineage cells, 
      oligodendrocyte precursor cells (OPCs) and postmitotic oligodendrocytes 
      selectively in the optic nerve, but not in the brain or spinal cord white matter 
      tracts. However, this normalizes later in development. The overall proportion of 
      OPCs and mature oligodendrocytes remains unchanged from P9 to P30 in all CNS 
      regions. This study identifies that BDNF exerts transient effects on 
      oligodendroglial lineage cells selectively in the optic nerve during postnatal 
      development. Taken together, this provides compelling evidence that BDNF 
      haploinsufficiency exerts modest effects upon oligodendroglial cell density and 
      lineage progression in vivo, suggesting its major role is restricted to promoting 
      oligodendrocyte myelination.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Nicholson, Madeline
AU  - Nicholson M
AD  - Department of Anatomy and Neuroscience, Faculty of Medicine, Dentistry and Health 
      Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Wood, Rhiannon J
AU  - Wood RJ
AD  - Department of Anatomy and Neuroscience, Faculty of Medicine, Dentistry and Health 
      Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - Fletcher, Jessica L
AU  - Fletcher JL
AD  - Department of Anatomy and Neuroscience, Faculty of Medicine, Dentistry and Health 
      Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
AD  - School of Psychology and Public Health, La Trobe University, Bundoora, Victoria 
      3086, Australia; Department of Pharmacology, University of Melbourne, Victoria 
      3010, Australia; The College of Public Health, Medical and Veterinary Sciences, 
      James Cook University, Townsville, Queensland 4811, Australia.
FAU - Murray, Simon S
AU  - Murray SS
AD  - Department of Anatomy and Neuroscience, Faculty of Medicine, Dentistry and Health 
      Sciences, University of Melbourne, Parkville, Victoria 3010, Australia; The 
      Florey Institute of Neuroscience and Mental Health, University of Melbourne, 
      Parkville, Victoria 3010, Australia.
FAU - Xiao, Junhua
AU  - Xiao J
AD  - Department of Anatomy and Neuroscience, Faculty of Medicine, Dentistry and Health 
      Sciences, University of Melbourne, Parkville, Victoria 3010, Australia; The 
      Florey Institute of Neuroscience and Mental Health, University of Melbourne, 
      Parkville, Victoria 3010, Australia. Electronic address: xiaoj@unimelb.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20180518
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
OTO - NOTNLM
OT  - BDNF
OT  - Central nervous system
OT  - Myelin
OT  - Myelination
OT  - OPC
OT  - Oligodendrocyte
EDAT- 2018/05/22 06:00
MHDA- 2018/05/22 06:00
CRDT- 2018/05/22 06:00
PHST- 2017/11/28 00:00 [received]
PHST- 2018/05/09 00:00 [revised]
PHST- 2018/05/15 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - S1044-7431(17)30375-5 [pii]
AID - 10.1016/j.mcn.2018.05.005 [doi]
PST - aheadofprint
SO  - Mol Cell Neurosci. 2018 May 18;90:12-21. doi: 10.1016/j.mcn.2018.05.005.