PMID- 29783061
OWN - NLM
STAT- MEDLINE
DCOM- 20191001
LR  - 20191218
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 152
DP  - 2018 Jul
TI  - Enhanced extinction of aversive memories in mice lacking SPARC-related protein 
      containing immunoglobulin domains 1 (SPIG1/FSTL4).
PG  - 61-70
LID - S1074-7427(18)30117-5 [pii]
LID - 10.1016/j.nlm.2018.05.010 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in synaptic 
      plasticity related to learning and memory. We previously reported that 
      SPARC-related protein containing immunoglobulin domains 1 (SPIG1, also known as 
      Follistatin-like protein 4, FSTL4) binds to pro-BDNF and negatively regulates 
      BDNF maturation; however, its neurological functions, particularly in learning 
      and memory, have not yet been elucidated. We herein examined the 
      electrophysiological and behavioral phenotypes of Spig1-knockout (Spig1-KO) mice. 
      Adult Spig1-KO mice exhibited greater excitability and facilitated long-term 
      potentiation (LTP) in the CA1 region of hippocampal slices than age- and 
      sex-matched wild-type (WT) mice. Facilitated LTP was reduced to the level of WT 
      by the bath application of an anti-BDNF antibody to hippocampal slices. A 
      step-through inhibitory avoidance learning paradigm revealed that the extinction 
      of aversive memories was significantly enhanced in adult Spig1-KO mice, while 
      they showed the normal acquisition of aversive memories; besides, spatial 
      reference memory formation was also normal in the standard Morris water maze 
      task. An intracerebroventricular (icv) injection of anti-BDNF in the process of 
      extinction learning transiently induced the recurrence of aversive memories in 
      Spig1-KO mice, but exerted no effects in WT mice. These results indicate a 
      critical role for SPIG1 in BDNF-mediated synaptic plasticity in extinction of 
      inhibitory avoidance memory.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Suzuki, Ryoko
AU  - Suzuki R
AD  - Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 
      Aichi, Japan.
FAU - Fujikawa, Akihiro
AU  - Fujikawa A
AD  - Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 
      Aichi, Japan.
FAU - Komatsu, Yukio
AU  - Komatsu Y
AD  - Division of Visual Information Processing, National Institute for Physiological 
      Sciences (NIPS), Aichi, Japan.
FAU - Kuboyama, Kazuya
AU  - Kuboyama K
AD  - Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 
      Aichi, Japan.
FAU - Tanga, Naomi
AU  - Tanga N
AD  - Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 
      Aichi, Japan; School of Life Sciences, The Graduate University for Advanced 
      Studies (SOKENDAI), Aichi, Japan.
FAU - Noda, Masaharu
AU  - Noda M
AD  - Division of Molecular Neurobiology, National Institute for Basic Biology (NIBB), 
      Aichi, Japan; School of Life Sciences, The Graduate University for Advanced 
      Studies (SOKENDAI), Aichi, Japan. Electronic address: madon@nibb.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180518
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Follistatin-Related Proteins)
RN  - 0 (Fstl4 protein, mouse)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Conditioning, Classical
MH  - Electroshock
MH  - Extinction, Psychological/*physiology
MH  - Follistatin-Related Proteins/genetics/*physiology
MH  - Hippocampus/physiology
MH  - *Long-Term Potentiation
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Synaptic Transmission
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Extinction learning
OT  - Hippocampus
OT  - Inhibitory avoidance learning
OT  - Knockout mice
OT  - Long-term potentiation
EDAT- 2018/05/22 06:00
MHDA- 2019/10/02 06:00
CRDT- 2018/05/22 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/05/11 00:00 [revised]
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2019/10/02 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - S1074-7427(18)30117-5 [pii]
AID - 10.1016/j.nlm.2018.05.010 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2018 Jul;152:61-70. doi: 10.1016/j.nlm.2018.05.010. Epub 
      2018 May 18.