PMID- 29783156
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 23
DP  - 2018 Jul
TI  - Transient impairment of olfactory threshold in acute multiple sclerosis relapse.
PG  - 74-77
LID - S2211-0348(18)30146-9 [pii]
LID - 10.1016/j.msard.2018.05.006 [doi]
AB  - BACKGROUND: Impairment of olfactory threshold is a feature of early and active 
      relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease 
      activity and was reported to be transient. However, the timing of onset and 
      resolve of olfactory threshold impairment remains unclear. OBJECTIVE: To 
      prospectively assess the development of olfactory threshold in acute MS relapse 
      over time in comparison to stable MS patients. METHODS: In a prospective 
      observational design, we measured olfactory threshold by performing the Sniffin' 
      Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory 
      function) at baseline and after 4, 12 and 24 weeks. We included 30 RRMS patients 
      with acute MS relapse and 30 clinically stable RRMS patients (defined as no 
      relapse within the last 12 months) as a control group. RESULTS: Olfactory 
      threshold was impaired in patients with acute MS relapse at baseline (median 
      difference = -3.5; inter-quartile range [IQR] -4.5- - 2.5; p < 0.001), week 4 
      (-2.5; IQR -3.0 - -2.0; p < 0.001), week 12 (-1.5; IQR -2.0 - -0.5; p = 0.002) 
      and week 24 (-0.5; IQR -1.0 - 0.0; p = 0.159) compared to stable MS patients. Of 
      note, in relapsing patients in whom disease-modifying treatment was initiated or 
      escalated after relapse, threshold did not differ anymore from stable patients at 
      week 12 (-0.5; IQR -1.0 - 0.5; p = 0.247) and week 24 (0.0; IQR -1.0 - 1.0; 
      p = 0.753). CONCLUSIONS: Olfactory threshold impairment seems to be a transient 
      bystander feature of MS relapse. It may be correlated to the level of 
      inflammation within the CNS and might be a useful biomarker in this regard.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bsteh, Gabriel
AU  - Bsteh G
AD  - Department of Neurology, Medical University of Innsbruck, Austria. Electronic 
      address: gabriel.bsteh@i-med.ac.at.
FAU - Hegen, Harald
AU  - Hegen H
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Ladstatter, Felix
AU  - Ladstatter F
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Berek, Klaus
AU  - Berek K
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Amprosi, Matthias
AU  - Amprosi M
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Wurth, Sebastian
AU  - Wurth S
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Auer, Michael
AU  - Auer M
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Di Pauli, Franziska
AU  - Di Pauli F
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Deisenhammer, Florian
AU  - Deisenhammer F
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Lutterotti, Andreas
AU  - Lutterotti A
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
FAU - Berger, Thomas
AU  - Berger T
AD  - Department of Neurology, Medical University of Innsbruck, Austria.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20180526
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis, Relapsing-Remitting/*complications/diagnosis/drug 
      therapy/*physiopathology
MH  - Olfaction Disorders/diagnosis/*etiology/*physiopathology
MH  - *Olfactory Perception
MH  - Prospective Studies
MH  - Recurrence
MH  - *Sensory Thresholds
MH  - Time Factors
OTO - NOTNLM
OT  - Biomarker
OT  - Development
OT  - Multiple sclerosis
OT  - Olfactory threshold
OT  - Relapse
OT  - Time
EDAT- 2018/05/22 06:00
MHDA- 2018/10/30 06:00
CRDT- 2018/05/22 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/04/18 00:00 [revised]
PHST- 2018/05/07 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - S2211-0348(18)30146-9 [pii]
AID - 10.1016/j.msard.2018.05.006 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2018 Jul;23:74-77. doi: 10.1016/j.msard.2018.05.006. 
      Epub 2018 May 26.