PMID- 29783176
OWN - NLM
STAT- MEDLINE
DCOM- 20191028
LR  - 20191028
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 53
DP  - 2018 Sep
TI  - omega-3 and folic acid act against depressive-like behavior and oxidative damage in 
      the brain of rats subjected to early- or late-life stress.
PG  - 120-133
LID - S0899-9007(18)30094-7 [pii]
LID - 10.1016/j.nut.2018.03.006 [doi]
AB  - OBJECTIVES: To investigate the antidepressant and antioxidant effects of omega-3, 
      folic acid and n-acetylcysteine (NAC) in rats which were subjected to early or 
      late life stress. METHODS: Early stress was induced through maternal deprivation 
      (MD), while late life stress was induced using the chronic mild stress (CMS) 
      protocol. Young rats which were subjected to MD and the adult rats which were 
      subjected to CMS were treated with omega-3 fatty acids (0.72 g/kg), NAC 
      (20 mg/kg) or folic acid (50 mg/kg) once/day, for a period of 20 days. Then, the 
      animals' immobility times were evaluated using the forced swimming test. 
      Oxidative stress parameters were evaluated in the brain. RESULTS: Depressive-like 
      behavior induced by CMS was prevented by NAC and folic acid, and depressive-like 
      behavior induced by MD was prevented by NAC, folic acid and omega-3. NAC, folic 
      acid and omega-3 were able to exert antioxidant effects in the brain of rats 
      subjected to CMS or MD. These preventive treatments decreased the levels of 
      protein carbonylation and lipid peroxidation, and also decreased the 
      concentrations of nitrite/nitrate and reduced the activity of myeloperoxidase 
      activity in the rat brain which was induced by CMS or MD. NAC, folic acid and 
      omega-3 increased superoxide dismutase and catalase activities in the rat brain 
      subjected to early or late life stress. CONCLUSIONS: NAC, omega-3 and folic acid 
      may present interesting lines of treatment based on their antioxidant properties, 
      which cause an inhibition of behavioral and brain changes that occur from 
      stressful life events.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Reus, Gislaine Z
AU  - Reus GZ
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil. 
      Electronic address: Gislainereus@unesc.net.
FAU - Maciel, Amanda L
AU  - Maciel AL
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Abelaira, Helena M
AU  - Abelaira HM
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - de Moura, Airam B
AU  - de Moura AB
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - de Souza, Thays G
AU  - de Souza TG
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Dos Santos, Thais R
AU  - Dos Santos TR
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Darabas, Ana Caroline
AU  - Darabas AC
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Parzianello, Murilo
AU  - Parzianello M
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Matos, Danyela
AU  - Matos D
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Abatti, Mariane
AU  - Abatti M
AD  - Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, 
      University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Vieira, Ana Carolina
AU  - Vieira AC
AD  - Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, 
      University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Fucillini, Vanessa
AU  - Fucillini V
AD  - Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, 
      University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Michels, Monique
AU  - Michels M
AD  - Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, 
      University of Southern Santa Catarina, Criciuma, Brazil.
FAU - Dal-Pizzol, Felipe
AU  - Dal-Pizzol F
AD  - Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, 
      University of Southern Santa Catarina, Criciuma, Brazil; Center of Excellence in 
      Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Medical 
      Sciences, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil.
FAU - Quevedo, Joao
AU  - Quevedo J
AD  - Translational Psychiatry Laboratory, Graduate Program in Health Sciences, Health 
      Sciences Unit, University of Southern Santa Catarina, Criciuma, Brazil; Center of 
      Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, 
      McGovern Medical School, The University of Texas Health Science Center at 
      Houston, Houston, Texas, USA; Translational Psychiatry Program, Department of 
      Psychiatry and Behavioral Sciences, McGovern Medical School, The University of 
      Texas Health Science Center at Houston, Houston, Texas, USA; Neuroscience 
      Graduate Program, Graduate School of Biomedical Sciences, The University of Texas 
      Health Science Center at Houston, Houston, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180330
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Antioxidants/pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects
MH  - Depressive Disorder/*prevention & control
MH  - Disease Models, Animal
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Folic Acid/*pharmacology
MH  - Lipid Peroxidation/drug effects
MH  - Maternal Deprivation
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/complications
OTO - NOTNLM
OT  - Animal model of depression
OT  - Antidepressant
OT  - Folic acid
OT  - Major depressive disorder
OT  - Oxidative stress
OT  - omega-3
EDAT- 2018/05/22 06:00
MHDA- 2019/10/29 06:00
CRDT- 2018/05/22 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/02/14 00:00 [revised]
PHST- 2018/03/03 00:00 [accepted]
PHST- 2018/05/22 06:00 [pubmed]
PHST- 2019/10/29 06:00 [medline]
PHST- 2018/05/22 06:00 [entrez]
AID - S0899-9007(18)30094-7 [pii]
AID - 10.1016/j.nut.2018.03.006 [doi]
PST - ppublish
SO  - Nutrition. 2018 Sep;53:120-133. doi: 10.1016/j.nut.2018.03.006. Epub 2018 Mar 30.