PMID- 29785331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2160-9381 (Print)
IS  - 2160-9381 (Electronic)
IS  - 2160-9381 (Linking)
VI  - 8
IP  - 2
DP  - 2018 Apr
TI  - Nodular basal cell carcinoma of the face successfully treated with ingenol 
      mebutate 0.015% gel.
PG  - 129-131
LID - 10.5826/dpc.0802a12 [doi]
AB  - Surgical excision is the first-choice treatment for basal cell carcinoma (BCC). 
      Other treatments with topical agents such as 5-fluorouracil or imiquimod have 
      also been suggested for use in superficial BCC (sBCC). Ingenol mebutate (IM) is a 
      novel agent employed in the treatment of superficial actinic keratoses. The drug 
      has been also successfully used in the treatment of sBCC. A case of large nodular 
      BCC (nBCC) of the face in a 100-year-old inoperable woman is described. IM 0.015% 
      gel was applied once daily for three consecutive days. This dose regimen was 
      repeated for seven rounds within 11 months, with complete cure of the tumor. Mild 
      local skin reactions, which were tolerated well, were observed. Selected cases of 
      nBCC could be treated with IM gel, but the optimal concentration of the drug and 
      the standard dose regimen of treatment are yet to be determined.
FAU - Iannazzone, Silvia S
AU  - Iannazzone SS
AD  - Outpatient Department of Dermatology, Benevento North-East District, Local Health 
      Unit Benevento, Benevento, Italy.
FAU - Ingordo, Vito
AU  - Ingordo V
AD  - Outpatient Department of Dermatology, District n. 6, Local Health Unit Taranto, 
      Taranto, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180430
PL  - Austria
TA  - Dermatol Pract Concept
JT  - Dermatology practical & conceptual
JID - 101585990
PMC - PMC5955081
OTO - NOTNLM
OT  - ingenol mebutate
OT  - nodular basal cell carcinoma
OT  - non-melanoma skin cancer
OT  - therapy
COIS- Competing interests: The authors have no conflicts of interest to disclose.
EDAT- 2018/05/23 06:00
MHDA- 2018/05/23 06:01
PMCR- 2018/04/30
CRDT- 2018/05/23 06:00
PHST- 2017/10/05 00:00 [received]
PHST- 2017/11/16 00:00 [accepted]
PHST- 2018/05/23 06:00 [entrez]
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2018/05/23 06:01 [medline]
PHST- 2018/04/30 00:00 [pmc-release]
AID - dp0802a12 [pii]
AID - 10.5826/dpc.0802a12 [doi]
PST - epublish
SO  - Dermatol Pract Concept. 2018 Apr 30;8(2):129-131. doi: 10.5826/dpc.0802a12. 
      eCollection 2018 Apr.