PMID- 29785745
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20190102
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 18
IP  - 8
DP  - 2018 Aug
TI  - Use of proton pump inhibitors is associated with increased mortality due to 
      nosocomial pneumonia in bedridden patients receiving tube feeding.
PG  - 1215-1218
LID - 10.1111/ggi.13450 [doi]
AB  - AIM: To investigate the association between the use of proton pump inhibitors 
      (PPI) and nosocomial pneumonia and gastrointestinal bleeding in bedridden 
      patients receiving tube feeding. METHODS: A total of 116 bedridden hospitalized 
      patients receiving tube feeding, of which 80 were supported by percutaneous 
      endoscopic gastrostomy and 36 by nasogastric tube, were included in the present 
      study. The patients were divided into two groups: 62 patients treated with PPI 
      (PPI group) and 54 patients without PPI (non-PPI group). Mortality due to 
      nosocomial pneumonia was evaluated using the Kaplan-Meier approach and the 
      log-rank test. RESULTS: A total of 36 patients (31%) died of nosocomial pneumonia 
      during the observation period; the mortality rate due to nosocomial pneumonia was 
      significantly higher in the PPI group than in the non-PPI group (P = 0.0395). Cox 
      proportional hazard analysis showed that the use of PPI and lower levels of serum 
      albumin were independent predictors of 2-year mortality due to nosocomial 
      pneumonia. Gastrointestinal bleeding was observed in four patients in the non-PPI 
      group (7.7%) and in one patient in the PPI group (1.6%); there was no significant 
      difference between the two groups. CONCLUSION: The use of PPI in bedridden 
      tube-fed patients was independently associated with mortality due to nosocomial 
      pneumonia, and the PPI group had a non-significant lower incidence of 
      gastrointestinal bleeding than the non-PPI group. Geriatr Gerontol Int 2018; 18: 
      1215-1218.
CI  - (c) 2018 The Authors Geriatrics & Gerontology International published by John Wiley 
      & Sons Australia, Ltd on behalf of Japan Geriatrics Society.
FAU - Hamai, Kosuke
AU  - Hamai K
AUID- ORCID: 0000-0002-8654-5532
AD  - Department of Respiratory Medicine, Hiroshima Prefectural Hospital, Hiroshima, 
      Japan.
AD  - Department of Internal Medicine, Rikita Hospital, Hiroshima, Japan.
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Iwamoto, Hiroshi
AU  - Iwamoto H
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Ohshimo, Shinichiro
AU  - Ohshimo S
AD  - Department of Emergency and Critical Care Medicine, Graduate School of Biomedical 
      and Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Wakabayashi, Yu
AU  - Wakabayashi Y
AD  - Department of Internal Medicine, Rikita Hospital, Hiroshima, Japan.
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Ihara, Daisuke
AU  - Ihara D
AD  - Department of Internal Medicine, Rikita Hospital, Hiroshima, Japan.
AD  - Department of Respiratory Medicine, Hiroshima City Hiroshima Citizens Hospital, 
      Hiroshima, Japan.
FAU - Fujitaka, Kazunori
AU  - Fujitaka K
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Hamada, Hironobu
AU  - Hamada H
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Ono, Koichi
AU  - Ono K
AD  - Department of Internal Medicine, Rikita Hospital, Hiroshima, Japan.
FAU - Hattori, Noboru
AU  - Hattori N
AD  - Department of Molecular and Internal Medicine, Graduate School of Biomedical and 
      Health Sciences, Hiroshima University, Hiroshima, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180522
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bedridden Persons
MH  - Cohort Studies
MH  - Enteral Nutrition/adverse effects/methods
MH  - Female
MH  - Geriatric Assessment
MH  - Healthcare-Associated Pneumonia/*etiology/*mortality/physiopathology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Intubation, Gastrointestinal/*adverse effects/methods
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Factors
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - bedridden
OT  - mortality
OT  - nosocomial pneumonia
OT  - proton pump inhibitors
OT  - tube feeding
EDAT- 2018/05/23 06:00
MHDA- 2019/01/03 06:00
CRDT- 2018/05/23 06:00
PHST- 2017/11/16 00:00 [received]
PHST- 2018/04/18 00:00 [revised]
PHST- 2018/04/25 00:00 [accepted]
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
PHST- 2018/05/23 06:00 [entrez]
AID - 10.1111/ggi.13450 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2018 Aug;18(8):1215-1218. doi: 10.1111/ggi.13450. Epub 2018 
      May 22.